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anti-NDUFS7 antibody :: Rabbit NDUFS7 Polyclonal Antibody

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Catalog # MBS9203560
Unit / Price
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  0.08 mL  /  $165 +1 FREE 8GB USB
  0.4 mL  /  $370 +1 FREE 8GB USB
Western Blot (WB)
Product Name

NDUFS7, Polyclonal Antibody

Popular Item
Full Product Name

NDUFS7 Antibody (Center)

Product Synonym Names
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7; mitochondrial; Complex I-20kD; CI-20kD; NADH-ubiquinone oxidoreductase 20 kDa subunit; PSST subunit; NDUFS7
Antibody/Peptide Pairs
NDUFS7 peptide (MBS9229140) is used for blocking the activity of NDUFS7 antibody (MBS9203560)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
119-146
OMIM
252010
3D Structure
ModBase 3D Structure for O75251
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human, mouse (Predicted Reactivity: Bovine)
Specificity
This NDUFS7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 119-146 amino acids from the Central region of human NDUFS7.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Calculated MW
23564
Function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Cellular Location
Mitochondrion.
Preparation and Storage
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-NDUFS7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-NDUFS7 antibody
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Applications Tested/Suitable for anti-NDUFS7 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-NDUFS7 antibody
WB~~1:1000

Western Blot (WB) of anti-NDUFS7 antibody
NDUFS7 Antibody (Center) western blot analysis in Hela cell line and mouse cerebellum,heart tissue lysates (35ug/lane).This demonstrates the NDUFS7 antibody detected the NDUFS7 protein (arrow).
anti-NDUFS7 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for NDUFS7. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
NADH dehydrogenase
NCBI Official Synonym Full Names
NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)
NCBI Official Symbol
NDUFS7  [Similar Products]
NCBI Official Synonym Symbols
PSST; CI-20; MY017; CI-20KD
  [Similar Products]
NCBI Protein Information
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
UniProt Protein Name
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
UniProt Synonym Protein Names
Complex I-20kD; CI-20kD; NADH-ubiquinone oxidoreductase 20 kDa subunit; PSST subunit
UniProt Gene Name
NDUFS7  [Similar Products]
UniProt Synonym Gene Names
CI-20kD  [Similar Products]
UniProt Entry Name
NDUS7_HUMAN
NCBI Summary for NDUFS7
This gene encodes a protein that is a subunit of one of the complexes that forms the mitochondrial respiratory chain. This protein is one of over 40 subunits found in complex I, the nicotinamide adenine dinucleotide (NADH):ubiquinone oxidoreductase. This complex functions in the transfer of electrons from NADH to the respiratory chain, and ubiquinone is believed to be the immediate electron acceptor for the enzyme. Mutations in this gene cause Leigh syndrome due to mitochondrial complex I deficiency, a severe neurological disorder that results in bilaterally symmetrical necrotic lesions in subcortical brain regions. [provided by RefSeq, Jul 2008]
UniProt Comments for NDUFS7
NDUFS7: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Defects in NDUFS7 are a cause of Leigh syndrome (LS). LS is a severe neurological disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions. Defects in NDUFS7 are a cause of mitochondrial complex I deficiency (MT-C1D). A disorder of the mitochondrial respiratory chain that causes a wide range of clinical disorders, from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease. Belongs to the complex I 20 kDa subunit family.

Protein type: EC 1.6.99.3; Oxidoreductase; Mitochondrial; EC 1.6.5.3; Energy Metabolism - oxidative phosphorylation

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: neuron projection; cell soma; mitochondrial inner membrane; mitochondrial respiratory chain complex I

Molecular Function: oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor; protein binding; protease binding; NADH dehydrogenase (ubiquinone) activity; 4 iron, 4 sulfur cluster binding; metal ion binding; quinone binding; NADH dehydrogenase activity

Biological Process: cellular metabolic process; mitochondrial respiratory chain complex I assembly; mitochondrial electron transport, NADH to ubiquinone

Disease: Leigh Syndrome
Product References and Citations for anti-NDUFS7 antibody
Hyslop S.J., et al. Genomics 37:375-380(1996).
Grimwood J., et al. Nature 428:529-535(2004).
Murray J., et al. J. Biol. Chem. 278:13619-13622(2003).
Burkard T.R., et al. BMC Syst. Biol. 5:17-17(2011).
Triepels R.H., et al. Ann. Neurol. 45:787-790(1999).

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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