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anti-Aak1 antibody :: Rabbit Aak1 Polyclonal Antibody

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Catalog # MBS9214771
Unit / Price
  0.08 mL  /  $150 +1 FREE 8GB USB
  0.4 mL  /  $340 +1 FREE 8GB USB
Product Name

Aak1, Polyclonal Antibody

Also Known As

Mouse Aak1 Antibody (Center)

Product Synonym Names
AP2-associated protein kinase 1; Adaptor-associated kinase 1; Aak1; Kiaa1048
Antibody/Peptide Pairs
Aak1 peptide (MBS9220937) is used for blocking the activity of Aak1 antibody (MBS9214771)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
279-306
Immunogen Sequence Length
878
3D Structure
ModBase 3D Structure for Q3UHJ0
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Mouse (Predicted Reactivity: Bovine, Human, Pig, Rat)
Specificity
This Mouse Aak1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 279-306 amino acids from the Central region of mouse Aak1.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (lot specific)
Antigen Type
Synthetic Peptide
Antigen Source
MOUSE
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-Aak1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-Aak1 antibody
Aak1 phosphorylates the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2). May play a role in regulating aspects of clathrin-mediated endocytosis (By similarity).
Product Categories/Family for anti-Aak1 antibody
Applications Tested/Suitable for anti-Aak1 antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-Aak1 antibody
WB~~1:1000

Western Blot (WB) of anti-Aak1 antibody
Mouse Aak1 Antibody (Center) western blot analysis in mouse bladder tissue lysates (35ug/lane).This demonstrates the Aak1 antibody detected the Aak1 protein (arrow).
anti-Aak1 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-Aak1 antibody
Mouse Aak1 Antibody (Center) (MBS9214771)immunohistochemistry analysis in formalin fixed and paraffin embedded mouse brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Mouse Aak1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
anti-Aak1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for Aak1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
Mouse (Predicted Reactivity: Bovine, Human, Pig, Rat)NP_808430.2[Other Products]
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
103346
NCBI Official Full Name
AP2 associated kinase 1 isoform 1
NCBI Official Synonym Full Names
AP2 associated kinase 1
NCBI Official Symbol
NCBI Official Synonym Symbols
C79663; R75501; AU067724; AU067726; BC028270; mKIAA1048; 9630042K20; D6Ertd245e; 5530400K14Rik
  [Similar Products]
NCBI Protein Information
AP2 associated kinase 1
UniProt Protein Name
AP2-associated protein kinase 1
UniProt Synonym Protein Names
Adaptor-associated kinase 1
UniProt Gene Name
UniProt Synonym Gene Names
Kiaa1048  [Similar Products]
UniProt Entry Name
AAK1_MOUSE
UniProt Comments for Aak1
AAK1: an NAK kinase. Plays a regulatory role in clathrin-mediated endocytosis, including the regulation of fatty acid synthesis and cholesterol synthesis.

Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; EC 2.7.11.1; Kinase, protein; Other group; NAK family

Cellular Component: membrane; plasma membrane; coated pit

Molecular Function: transferase activity; protein serine/threonine kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; ATP binding; protein kinase activity

Biological Process: endocytosis; phosphorylation; protein amino acid phosphorylation
Product References and Citations for anti-Aak1 antibody
Munton, R.P., et al. Mol. Cell Proteomics 6(2):283-293(2007)
Nishimura, M., et al. DNA Res. 11(5):315-323(2004)
Jha, A., et al. J. Biol. Chem. 279(3):2281-2290(2004)
Zambrowicz, B.P., et al. Proc. Natl. Acad. Sci. U.S.A. 100(24):14109-14114(2003)
Hansen, J., et al. Proc. Natl. Acad. Sci. U.S.A. 100(17):9918-9922(2003)

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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