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anti-ACACA antibody :: Rabbit ACACA Polyclonal Antibody

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Catalog # MBS9209560
Unit / Price
  0.08 mL  /  $150 +1 FREE 8GB USB
  0.4 mL  /  $340 +1 FREE 8GB USB
Western Blot (WB)
Product Name

ACACA, Polyclonal Antibody

Also Known As

ACACA Antibody (C-term)

Product Synonym Names
Acetyl-CoA carboxylase 1; ACC1; ACC-alpha; Biotin carboxylase; ACACA; ACAC; ACC1; ACCA
Antibody/Peptide Pairs
ACACA peptide (MBS9222308) is used for blocking the activity of ACACA antibody (MBS9209560)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
2010-2039
Immunogen Sequence Length
2,383
OMIM
200350
3D Structure
ModBase 3D Structure for Q13085
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human (Predicted Reactivity: Bovine, Mouse, Rat)
Specificity
This ACACA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2010-2039 amino acids from the C-terminal region of human ACACA.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (lot specific)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-ACACA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ACACA antibody
Acetyl-CoA carboxylase (ACC) is a complex multifunctional
enzyme system. ACC is a biotin-containing enzyme which catalyzes
the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting
step in fatty acid synthesis. There are two ACC forms, alpha and
beta, encoded by two different genes. ACC-alpha is highly enriched
in lipogenic tissues. The enzyme is under long term control at the
transcriptional and translational levels and under short term
regulation by the phosphorylation/dephosphorylation of targeted
serine residues and by allosteric transformation by citrate or
palmitoyl-CoA. Multiple alternatively spliced transcript variants
divergent in the 5' sequence and encoding distinct isoforms have
been found for this gene.
Applications Tested/Suitable for anti-ACACA antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-ACACA antibody
WB~~1:1000

Western Blot (WB) of anti-ACACA antibody
ACACA Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the ACACA antibody detected the ACACA protein (arrow).
anti-ACACA antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for ACACA. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
Human (Predicted Reactivity: Bovine, Mouse, Rat)NP_942133.1; NP_942134.1; NP_942135.1; NP_942136.1[Other Products]
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
265554
NCBI Official Full Name
acetyl-CoA carboxylase 1 isoform 1
NCBI Official Synonym Full Names
acetyl-CoA carboxylase alpha
NCBI Official Symbol
ACACA  [Similar Products]
NCBI Official Synonym Symbols
ACC; ACAC; ACC1; ACCA; ACACAD
  [Similar Products]
NCBI Protein Information
acetyl-CoA carboxylase 1
UniProt Protein Name
Acetyl-CoA carboxylase 1
UniProt Synonym Protein Names
ACC-alphaIncluding the following 1 domains:Biotin carboxylase (EC:6.3.4.14
UniProt Gene Name
ACACA  [Similar Products]
UniProt Synonym Gene Names
ACAC; ACC1; ACCA; ACC1  [Similar Products]
UniProt Entry Name
ACACA_HUMAN
NCBI Summary for ACACA
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ACACA
ACC1: a subunit of acetyl-CoA carboxylase (ACC), a multifunctional enzyme system. Catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Phosphorylation by AMPK or PKA inhibits the enzymatic activity of ACC. ACC-alpha is the predominant isoform in liver, adipocyte and mammary gland. ACC-beta is the major isoform in skeletal muscle and heart. Phosphorylation regulates its activity.

Protein type: EC 6.4.1.2; Carbohydrate Metabolism - pyruvate; Carbohydrate Metabolism - propanoate; Lipid Metabolism - fatty acid biosynthesis; EC 6.3.4.14; Ligase

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: mitochondrion; cytoplasm; nucleolus; cytosol; actin cytoskeleton

Molecular Function: protein binding; acetyl-CoA carboxylase activity; metal ion binding; biotin carboxylase activity; ATP binding

Biological Process: vitamin metabolic process; acetyl-CoA metabolic process; positive regulation of cellular metabolic process; lipid homeostasis; triacylglycerol biosynthetic process; cellular lipid metabolic process; carnitine shuttle; biotin metabolic process; protein homotetramerization; multicellular organismal protein metabolic process; energy reserve metabolic process; tissue homeostasis; fatty acid biosynthetic process; water-soluble vitamin metabolic process

Disease: Acetyl-coa Carboxylase Deficiency
Product References and Citations for anti-ACACA antibody
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Kim, C.W., et al. Proc. Natl. Acad. Sci. U.S.A. 107(21):9626-9631(2010)
Zhao, L.F., et al. Endocr. J. 57(4):317-324(2010)

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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