• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

anti-BTK antibody :: Rabbit BTK Polyclonal Antibody

Scan QR to view Datasheet
Catalog # MBS8234916
Unit / Price
  0.03 mL  /  $165 +1 FREE 8GB USB
  0.1 mL  /  $245 +1 FREE 8GB USB
  0.2 mL  /  $350 +1 FREE 8GB USB
Western Blot (WB)
Product Name

BTK, Polyclonal Antibody

Popular Item
Full Product Name

Anti-BTK (pY223) Antibody

Product Synonym Names
AGMX1; ATK; BPK; Tyrosine-protein kinase BTK; Agammaglobulinemia tyrosine kinase; ATK; B-cell progenitor kinase; BPK; Bruton tyrosine kinase
Product Gene Name
Antibody/Peptide Pairs
BTK peptide (MBS8229243) is used for blocking the activity of BTK antibody (MBS8234916)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
300300
3D Structure
ModBase 3D Structure for Q06187
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Bovine
Specificity
Recognizes endogenous levels of BTK (pY223) protein.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human BTK (pY223). The exact sequence is proprietary.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-BTK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-BTK antibody
Rabbit polyclonal antibody to BTK (pY223)
Applications Tested/Suitable for anti-BTK antibody
Western Blot (WB)
Application Notes for anti-BTK antibody
WB (1/500 - 1/1000)

Western Blot (WB) of anti-BTK antibody
Western blot analysis of BTK (pY223) expression in DLD (A), mouse liver (B), rat liver (C), rat kidney (D) whole cell lysates.
anti-BTK antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for BTK. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
79,937 Da
NCBI Official Full Name
tyrosine-protein kinase BTK isoform 1
NCBI Official Synonym Full Names
Bruton agammaglobulinemia tyrosine kinase
NCBI Official Symbol
NCBI Official Synonym Symbols
AT; ATK; BPK; XLA; IMD1; AGMX1; PSCTK1
  [Similar Products]
NCBI Protein Information
tyrosine-protein kinase BTK
UniProt Protein Name
Tyrosine-protein kinase BTK
UniProt Synonym Protein Names
Agammaglobulinemia tyrosine kinase; ATK; B-cell progenitor kinase; BPK; Bruton tyrosine kinase
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
AGMX1; ATK; BPK; ATK; BPK  [Similar Products]
UniProt Entry Name
BTK_HUMAN
NCBI Summary for BTK
The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]
UniProt Comments for BTK
Btk: a tyrosine kinase of the Tec family. Plays a crucial role in B-cell ontogeny. Defects cause X-linked agammaglobulinemia, an immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement. Truncated splice forms found in childhood leukemias may underlie radiation resistance of tumors through inhibition of apoptosis.

Protein type: Kinase, protein; Protein kinase, tyrosine (non-receptor); EC 2.7.10.2; Protein kinase, TK; TK group; Tec family

Chromosomal Location of Human Ortholog: Xq21.33-q22

Cellular Component: extrinsic to internal side of plasma membrane; mast cell granule; intracellular membrane-bound organelle; perinuclear region of cytoplasm; cytoplasm; plasma membrane; cytoplasmic vesicle; nucleus; cytosol; lipid raft

Molecular Function: identical protein binding; protein binding; phosphatidylinositol-3,4,5-triphosphate binding; metal ion binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding; receptor binding

Biological Process: I-kappaB kinase/NF-kappaB cascade; adaptive immune response; B cell activation; transcription, DNA-dependent; cell maturation; calcium-mediated signaling; T cell receptor signaling pathway; protein amino acid phosphorylation; regulation of cell proliferation; toll-like receptor 2 signaling pathway; activation of NF-kappaB transcription factor; regulation of B cell apoptosis; regulation of B cell cytokine production; MyD88-dependent toll-like receptor signaling pathway; B cell receptor signaling pathway; histamine secretion by mast cell; toll-like receptor signaling pathway; positive regulation of B cell differentiation; innate immune response; mesoderm development; cell differentiation; toll-like receptor 4 signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Isolated Growth Hormone Deficiency, Type Iii; Agammaglobulinemia, X-linked
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000