NP_005645.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
COUP transcription factor 1
NCBI Official Synonym Full Names
nuclear receptor subfamily 2, group F, member 1
NCBI Official Synonym Symbols
EAR3; BBOAS; EAR-3; NR2F2; SVP44; BBSOAS; ERBAL3; TFCOUP1; COUP-TFI; TCFCOUP1 [Similar Products]
NCBI Protein Information
COUP transcription factor 1
UniProt Protein Name
COUP transcription factor 1
UniProt Synonym Protein Names
COUP transcription factor I; COUP-TF I; Nuclear receptor subfamily 2 group F member 1; V-erbA-related protein 3; EAR-3
UniProt Synonym Gene Names
UniProt Entry Name
COT1_HUMAN
NCBI Summary for NR2F1
The protein encoded by this gene is a nuclear hormone receptor and transcriptional regulator. The encoded protein acts as a homodimer and binds to 5'-AGGTCA-3' repeats. Defects in this gene are a cause of Bosch-Boonstra optic atrophy syndrome (BBOAS). [provided by RefSeq, Apr 2014]
UniProt Comments for NR2F1
NR2F1: Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG. Binds DNA as dimer; homodimer and probable heterodimer with NR2F6. Interacts with COPS2. Inhibited by gonadotropin in granulosa cells. Belongs to the nuclear hormone receptor family. NR2 subfamily.
Protein type: Nuclear receptor; Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 5q14
Cellular Component: nucleoplasm; nucleus
Molecular Function: protein binding; ligand-dependent nuclear receptor activity; zinc ion binding; sequence-specific DNA binding; transcription coactivator activity; steroid hormone receptor activity; transcription factor activity
Biological Process: transcription initiation from RNA polymerase II promoter; intracellular receptor-mediated signaling pathway; neuron migration; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; gene expression; cerebral cortex regionalization; negative regulation of transcription from RNA polymerase II promoter; signal transduction
Disease: Bosch-boonstra-schaaf Optic Atrophy Syndrome
Product References and Citations for anti-NR2F1 antibody
Davis, O.S., et al. Behav. Genet. (2010) In press : Dai, K., et al. Arterioscler. Thromb. Vasc. Biol. 30(3):568-574(2010) Montemayor, C., et al. PLoS ONE 5 (1), E8910 (2010) : Bush, Z.M., et al. Pituitary 13(1):1-7(2010) Johnson, M.P., et al. Hum. Genet. 126(5):655-666(2009)
Research Articles on NR2F1
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Products associated with anti-NR2F1 antibody
Pathways associated with anti-NR2F1 antibody
Diseases associated with anti-NR2F1 antibody
Organs/Tissues associated with anti-NR2F1 antibody
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