NP_000908.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
prolyl 4-hydroxylase subunit alpha-1 isoform 1
NCBI Official Synonym Full Names
prolyl 4-hydroxylase, alpha polypeptide I
NCBI Official Synonym Symbols
NCBI Protein Information
prolyl 4-hydroxylase subunit alpha-1
UniProt Protein Name
Prolyl 4-hydroxylase subunit alpha-1
UniProt Synonym Protein Names
Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1
UniProt Synonym Gene Names
UniProt Entry Name
P4HA1_HUMAN
NCBI Summary for P4HA1
This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
UniProt Comments for P4HA1
P4HA1: Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. Belongs to the P4HA family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Amino Acid Metabolism - arginine and proline; Mitochondrial; EC 1.14.11.2; Endoplasmic reticulum; Oxidoreductase
Chromosomal Location of Human Ortholog: 10q22.1
Cellular Component: mitochondrion; membrane; intracellular membrane-bound organelle; endoplasmic reticulum; endoplasmic reticulum lumen
Molecular Function: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; protein binding; procollagen-proline 4-dioxygenase activity; L-ascorbic acid binding; iron ion binding
Biological Process: collagen fibril organization; peptidyl-proline hydroxylation to 4-hydroxy-L-proline
Product References and Citations for anti-P4HA1 antibody
Rose, J. Phd, et al. Mol. Med. (2010) In press : Gorres, K.L., et al. PLoS ONE 4 (11), E7635 (2009) : Koivunen, P., et al. J. Biol. Chem. 281(39):28712-28720(2006) Fahling, M., et al. J. Biol. Chem. 281(36):26089-26101(2006) Grimmer, C., et al. Am. J. Pathol. 169(2):491-502(2006)
Research Articles on P4HA1
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Products associated with anti-P4HA1 antibody
Diseases associated with anti-P4HA1 antibody
Organs/Tissues associated with anti-P4HA1 antibody
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