P32455.2
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Guanylate-binding protein 1
NCBI Official Synonym Full Names
guanylate binding protein 1
NCBI Protein Information
guanylate-binding protein 1
UniProt Protein Name
Guanylate-binding protein 1
UniProt Synonym Protein Names
GTP-binding protein 1; GBP-1; HuGBP-1; Guanine nucleotide-binding protein 1; Interferon-induced guanylate-binding protein 1
UniProt Synonym Gene Names
UniProt Entry Name
GBP1_HUMAN
NCBI Summary for GBP1
Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. [provided by RefSeq, Jul 2008]
UniProt Comments for GBP1
GBP1: a member of the family of large GTP-binding proteins (GBPs) that is inducible by interferon. Possesses a high GTP hydrolysis activity. GBPs are the most abundant cellular proteins expressed in response to interferon-gamma (IFN-gamma). IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta) strongly induce the expression of GBP-1, -2, and -3.
Protein type: Hydrolase; Cell adhesion; Vesicle
Chromosomal Location of Human Ortholog: 1p22.2
Cellular Component: cytosol; extracellular region; Golgi membrane; plasma membrane
Molecular Function: actin binding; cytokine binding; enzyme binding; GTP binding; GTPase activity; Hsp90 protein binding; identical protein binding; protein binding; spectrin binding
Biological Process: cytokine and chemokine mediated signaling pathway; defense response to virus; metabolic process; negative regulation of T cell receptor signaling pathway; regulation of calcium-mediated signaling
Research Articles on GBP1
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Products associated with anti-GBP1 antibody
Pathways associated with anti-GBP1 antibody
Diseases associated with anti-GBP1 antibody
Organs/Tissues associated with anti-GBP1 antibody
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