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anti-NR2E3 antibody :: Rabbit anti-Bovine NR2E3 Polyclonal Antibody

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Catalog # MBS623198
Unit / Price
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  0.2 mg  /  $655 +1 FREE 8GB USB
Western Blot
Product Name

NR2E3, Polyclonal Antibody

Popular Item
Full Product Name

NR2E3 (Nuclear receptor subfamily 2, group E, Member 3, ESCS, MGC49976, Nuclear receptor subfamily 2 group E member 3, Photoreceptor-specific nuclear receptor, PNR, rd7, Retina-specific nuclear receptor, RNR, RP37)

Product Synonym Names
Anti -NR2E3 (Nuclear receptor subfamily 2, group E, Member 3, ESCS, MGC49976, Nuclear receptor subfamily 2 group E member 3, Photoreceptor-specific nuclear receptor, PNR, rd7, Retina-specific nuclear receptor, RNR, RP37)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 15; NC_000015.9 (72102894..72110600). Location: 15q22.32
3D Structure
ModBase 3D Structure for Q8IVZ9
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Bovine
Specificity
Recognizes the bovine NR2E3 protein at ~44kD. Species Sequence Homology: mouse, rat and human
Purity/Purification
Affinity Purified
Purified by Protein A affinty chromatography
Form/Format
Supplied as a liquid in 0.1M Tris-Glycine, pH7.4, 150mM sodium chloride, 0.05% sodium azide.
Immunogen
Full Length Recombinant NR2E3 protein (Q9Y5X4)
Positive Control
Bovine Retina tissue lysate
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-NR2E3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-NR2E3 antibody
NR2E3 protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects in this gene are a cause of enhanced S cone syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
Product Categories/Family for anti-NR2E3 antibody
Applications Tested/Suitable for anti-NR2E3 antibody
Western Blot (WB)
Application Notes for anti-NR2E3 antibody
Suitable for use in Western Blot.
Dilution: Western Blot: 2ug/ml

Western Blot of anti-NR2E3 antibody
Western Blot analysis: Bovine retina lysate was resolved by electrophoresis, transferred to PVDF and probed with MBS623198 (2ug/ml). Protein were visualized using a donkey anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence detection system
anti-NR2E3 antibody Western Blot (WB) image
NCBI/Uniprot data below describe general gene information for NR2E3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
35,540 Da[Similar Products]
NCBI Official Full Name
NR2E3 protein
NCBI Official Synonym Full Names
nuclear receptor subfamily 2, group E, member 3
NCBI Official Symbol
NR2E3  [Similar Products]
NCBI Official Synonym Symbols
PNR; RNR; rd7; ESCS; RP37; MGC49976
  [Similar Products]
NCBI Protein Information
photoreceptor-specific nuclear receptor; retina-specific nuclear receptor; photoreceptor cell-specific nuclear receptor variant 1
UniProt Protein Name
NR2E3 protein
UniProt Gene Name
NR2E3  [Similar Products]
UniProt Entry Name
Q8IVZ9_HUMAN
NCBI Summary for NR2E3
This protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects in this gene are a cause of enhanced S cone syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]
UniProt Comments for NR2E3
NR2E3: Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression. Defects in NR2E3 are a cause of enhanced S cone syndrome (ESCS). ESCS is an autosomal recessive retinopathy in which patients have increased sensitivity to blue light; perception of blue light is mediated by what is normally the least populous cone photoreceptor subtype, the S (short wavelength, blue) cones. ESCS is also associated with visual loss, with night blindness occurring from early in life, varying degrees of L (long, red)- and M (middle, green)-cone vision, and retinal degeneration. Defects in NR2E3 are the cause of retinitis pigmentosa type 37 (RP37). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP37 inheritance is autosomal dominant. Belongs to the nuclear hormone receptor family. NR2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor

Chromosomal Location of Human Ortholog: 15q23

Cellular Component: nucleoplasm; transcription factor complex; nucleus

Molecular Function: ligand-dependent nuclear receptor activity; protein binding; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity

Biological Process: transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; intracellular receptor-mediated signaling pathway; positive regulation of rhodopsin gene expression; negative regulation of transcription from RNA polymerase II promoter; signal transduction; negative regulation of cell proliferation; eye photoreceptor cell development; visual perception; retina development in camera-type eye; phototransduction; positive regulation of transcription from RNA polymerase II promoter; gene expression; steroid hormone mediated signaling

Disease: Retinitis Pigmentosa 37; Enhanced S-cone Syndrome
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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