P07478
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UniProt Related Accession #
NCBI Official Full Name
trypsinogen
NCBI Official Synonym Full Names
protease, serine, 2 (trypsin 2)
NCBI Official Synonym Symbols
TRY2; TRY8; TRYP2; MGC111183; MGC120174; MGC120175 [Similar Products]
NCBI Protein Information
trypsin-2; trypsin 2; trypsin II; trypsinogen 2; serine protease 2; anionic trypsinogen; protease serine 2 preproprotein; protease, serine, 2, preproprotein
UniProt Protein Name
Trypsin-2
UniProt Synonym Protein Names
Anionic trypsinogen; Serine protease 2; Trypsin II
UniProt Synonym Gene Names
UniProt Entry Name
TRY2_HUMAN
NCBI Summary for PRSS2
This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq]
UniProt Comments for PRSS2
trypsin 2: In the ileum, may be involved in defensin processing, including DEFA5. Belongs to the peptidase S1 family.
Protein type: Extracellular matrix; Secreted, signal peptide; Protease; Calcium-binding; Secreted; EC 3.4.21.4; Cell adhesion
Chromosomal Location of Human Ortholog: 7q34
Cellular Component: extracellular matrix; extracellular space; extracellular region
Molecular Function: protein binding; serine-type endopeptidase activity; calcium ion binding
Biological Process: extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis; positive regulation of cell adhesion; digestion; innate immune response; proteolysis; positive regulation of cell growth
Disease: Pancreatitis, Hereditary
Research Articles on PRSS2
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Pathways associated with anti-PRSS2 antibody
Diseases associated with anti-PRSS2 antibody
Organs/Tissues associated with anti-PRSS2 antibody
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