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anti-TLR2 antibody :: Goat TLR2 Polyclonal Antibody

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Catalog # MBS448048 (SPECIAL PROMOTIONAL PRICING for a limited time)
Unit / Price
  0.6 mg  /  $285 +1 FREE 8GB USB
Product Name

TLR2, Polyclonal Antibody

Popular Item
Also Known As

TLR2 Polyclonal Antibody

Product Synonym Names
Anti-TLR2; CD282; TIL4; toll/interleukin 1 receptor-like 4; toll/interleukin-1 receptor-like protein 4 antibody
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
784
Chromosome Location
Chromosome: 4; NC_000004.12 (153684252..153706091). Location: 4q32
OMIM
246300
3D Structure
ModBase 3D Structure for O60603
Clonality
Polyclonal
Isotype
IgG
Host
Goat
Species Reactivity
Reacts against human, rat, mouse, canine, and monkey proteins
Specificity
Using liver, MDA-MD-435S and RAW264.7 cell lysates detects a band 85-90 kDa by Western blot.
Form/Format
Polyclonal antibody supplied as (3 mg/ml) aliquot in PBS, 20% glycerol and 0.05% sodium azide. This antibody is epitope-affinity purified from goat antiserum.
Gene Identifier
ENSG00000137462
Immunogen
Purified recombinant peptide derived from within residues 736 aa to the C-terminus of human TLR2 produced in E. coli.
Antigen
Purified recombinant peptide derived from within residues 736 aa to the C-terminus of human TLR2 produced in E. coli.
Handling
The antibody solution should be gently mixed before use.
Preparation and Storage
Store at -20 degree C for long term storage. Store at 2-8 degree C for up to one month.Avoid freeze/thaw cycles
Other Notes
Small volumes of anti-TLR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TLR2 antibody
Toll-like receptor 2

Goat polyclonal antibody to TLR2. It is a 84 kDa type I transmembrane glycoprotein and a member of TLR family. It contains many leucine-rich repeat sequences and the intracellular Toll Interleukin Receptor Domain. TLR2 forms heterodimer with TLR1 and TLR6. It is expressed in peripheral blood leukocytes, and highly expressed in monocytes in bone marrow, lymph nodes, and spleen. It is also detectable in other tissues. This protein recognizes molecular patterns of bacteria, fungi, protozoan pathogens and stimulates pro-inflammatory cytokines as part of innate immunity.
Applications Tested/Suitable for anti-TLR2 antibody
Western Blot (WB)
Application Notes for anti-TLR2 antibody
Western Blot: 1:500-1:2,000

Reactivity Chart of anti-TLR2 antibody
anti-TLR2 antibody Reactivity Chart image
Testing Data of anti-TLR2 antibody
anti-TLR2 antibody Testing Data image
NCBI/Uniprot data below describe general gene information for TLR2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
89,838 Da
NCBI Official Full Name
toll-like receptor 2
NCBI Official Synonym Full Names
toll-like receptor 2
NCBI Official Symbol
NCBI Official Synonym Symbols
TIL4; CD282
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NCBI Protein Information
toll-like receptor 2; toll/interleukin 1 receptor-like 4; toll/interleukin-1 receptor-like protein 4
UniProt Protein Name
Toll-like receptor 2
UniProt Synonym Protein Names
Toll/interleukin-1 receptor-like protein 4
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
TLR2_HUMAN
NCBI Summary for TLR2
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. [provided by RefSeq, Jul 2008]
UniProt Comments for TLR2
Function: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6.

Subunit structure: Interacts with LY96, TLR1 and TLR6 (via extracellular domain). Binds MYD88 (via TIR domain). Interacts with TICAM1. Ligand binding induces the formation of a heterodimer with TLR1 or TLR6. Interacts with CNPY3

By similarity. Interacts with ATG16L1. Ref.10 Ref.12

Subcellular location: Membrane; Single-pass type I membrane protein

By similarity.

Tissue specificity: Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues.

Domain: Ester-bound lipid substrates are bound through a crevice formed between the LRR 11 and LRR 12

By similarity.The ATG16L1-binding motif mediates interaction with ATG16L1 (Ref.12).

Post-translational modification: Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.

Polymorphism: Genetic variations in TLR2 are associated with susceptibility to leprosy [

MIM:246300]. Leprosy is a chronic disease associated with depressed cellular (but not humoral) immunity, the bacterium requires a lower temperature than 37 degrees Celsius and thrives particularly in peripheral Schwann cells and macrophages. The Trp-677 polymorphism in the intracellular domain of TLR2 has a role in susceptibility to lepromatous leprosy. Wild-type TLR2 mediates CD14-enhanced Mycobacterium leprae-dependent activation of NFKB1, but TLR2 containing the Trp-677 polymorphism did not. The impaired function of the Trp-677 polymorphism provides a molecular mechanism for the poor cellular immune response associated with lepromatous leprosy.

Sequence similarities: Belongs to the Toll-like receptor family.Contains 19 LRR (leucine-rich) repeats.Contains 1 LRRCT domain.Contains 1 TIR domain.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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