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anti-Nrxn1 antibody :: Goat NEUREXIN 1 Polyclonal Antibody

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Catalog # MBS622173
Unit / Price
  0.1 mg  /  $560 +1 FREE 8GB USB
anti-Nrxn1 antibody
Product Name

NEUREXIN 1 (Nrxn1), Polyclonal Antibody

Also Known As

NEUREXIN 1 (CT) (NRXN1, DKFZp313P2036, FLJ35941, Hs.22998, KIAA0578, Neurexin-1-alpha precursor, Neurexin-1-beta precursor, Neurexin I-alpha, Neurexin I-beta)

Product Synonym Names
Anti -NEUREXIN 1 (CT) (NRXN1, DKFZp313P2036, FLJ35941, Hs.22998, KIAA0578, Neurexin-1-alpha precursor, Neurexin-1-beta precursor, Neurexin I-alpha, Neurexin I-beta)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 6; NC_005105.2 (14050929..15354069, complement). Location: 6q12
3D Structure
ModBase 3D Structure for Q63372
Clonality
Polyclonal
Isotype
IgG
Host
Goat
Species Reactivity
Canine, Human, Mouse, Rat
Specificity
Recognizes an epitope within the CT region of human Neurexin 1 in cerebellum cell lysates at ~150kD. Species crossreactivity: Expected to react with Mouse, rat, and canine.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Form/Format
Supplied as a liquid in TBS, pH 7.3, 0.02% sodium azide, 0.5% BSA.
Immunogen
Peptide sequence C-KEKQPSSAKSSNKN from the C-Terminal region of NRXN1.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-Nrxn1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-Nrxn1 antibody
Neurexin 1 (NRXN1) is a transmembrane neuronal protein and member of the neurexin family, which act as cell adhesion molecules and receptors within the vertebrate nervous system.
Applications Tested/Suitable for anti-Nrxn1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-Nrxn1 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:32000
Western Blot: 0.05-0.1ug/ml
NCBI/Uniprot data below describe general gene information for Nrxn1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
167,923 Da[Similar Products]
NCBI Official Full Name
neurexin 1
NCBI Official Synonym Full Names
neurexin 1
NCBI Official Symbol
Nrxn1  [Similar Products]
NCBI Official Synonym Symbols
Nrxn1b
  [Similar Products]
NCBI Protein Information
neurexin 1; neurexin I-beta; neurexin-1-beta; neurexin I-alpha; neurexin-1-alpha; non-processed neurexin I-alpha
UniProt Protein Name
Neurexin-1-alpha
UniProt Synonym Protein Names
Neurexin I-alpha
Protein Family
UniProt Gene Name
Nrxn1  [Similar Products]
UniProt Entry Name
NRX1A_RAT
NCBI Summary for Nrxn1
neuronal cell recognition molecule; may have a role in synaptogenesis [RGD]
UniProt Comments for Nrxn1
NRXN1: Cell surface protein involved in cell-cell-interactions, excytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)- triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their calcium-dependent interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latroxin from spider venom. Belongs to the neurexin family. 4 isoforms of the human protein are produced by alternative promoter.

Protein type: Membrane protein, integral; Receptor, misc.

Cellular Component: presynaptic membrane; cell surface; endocytic vesicle; cell; integral to membrane; plasma membrane; cell junction

Molecular Function: protein binding; calcium channel regulator activity; acetylcholine receptor binding; calcium ion binding; cell adhesion molecule binding; calcium-dependent protein binding; receptor binding

Biological Process: prepulse inhibition; neurotransmitter secretion; social behavior; vocal learning; learning; positive regulation of synaptic transmission, glutamatergic; cerebellar granule cell differentiation; negative regulation of filopodium formation; heterophilic cell adhesion; synaptic transmission; positive regulation of synaptogenesis; establishment of protein localization; synaptogenesis; adult behavior; calcium-dependent cell-cell adhesion; protein heterotetramerization; neuron adhesion; angiogenesis; cell adhesion; neuromuscular process controlling balance; vesicle docking during exocytosis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with anti-Nrxn1 antibody
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