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anti-Gad2 antibody :: Rabbit GLUTAMATE DECARBOXYLASE 1/2 Polyclonal Antibody

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Catalog # MBS221561
Unit / Price
  0.1 mL  /  $555 +1 FREE 8GB USB
anti-Gad2 antibody
Product Name

GLUTAMATE DECARBOXYLASE 1/2 (Gad2), Polyclonal Antibody

Full Product Name

RABBIT ANTI GLUTAMATE DECARBOXYLASE 1/2

Product Gene Name

anti-Gad2 antibody

[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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3D Structure
ModBase 3D Structure for Q05683
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Cat, Human, Mouse
Specificity
This product recognises both molecular forms of glutamate decarboxylase, GAD1 (GAD67) and GAD2 (GAD65), the enzyme which converts glutamic acid to gamma -aminobutyric acid (GABA), the major inhibitory transmitter in the higher brain region.
Form/Format
Purified
Purified IgG - liquid
Perservative Stabilisers
0.09% Sodium Azide (NaN3)
Immunogen
Synthetic peptide sequence D-F-L-I-E-E-I-E-R-L-G-Q-D-L from the C terminus of rat GAD2
Histology Positive Control Tissue
Antiserum Preparation
Antiserum to glutamic acid decarboxylase was raised by repeated immunisation of with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography on protein A.
Target Species
Rat
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Other Notes
Small volumes of anti-Gad2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for
anti-Gad2 antibody
This product recognises both molecular forms of glutamate decarboxylase, GAD1 (GAD67) and GAD2 (GAD65), the enzyme which converts glutamic acid to gamma -aminobutyric acid (GABA), the major inhibitory transmitter in the higher brain region.
Applications Tested/Suitable for anti-Gad2 antibody
Immunohistology Frozen, ELISA (EIA), Immunofluorescence (IF), Immunohistology Paraffin, Western Blot (WB)
Application Notes for anti-Gad2 antibody
Western Blot: A doublet at approximately 65/67 kDa can be expected
Immunohistology - Frozen: Minimum Dilution: 1/200; Maximum Dilution: 1/5000
Western Blotting: Minimum Dilution: 1/1000; Maximum Dilution: 1/10000
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NCBI/Uniprot data below describe general gene information for Gad2. It may not necessarily be applicable to this product.
NCBI GI #
6978871
NCBI GeneID
24380
NCBI Accession #
NP_036695.1 [Other Products]
NCBI GenBank Nucleotide #
NM_012563.1 [Other Products]
UniProt Primary Accession #
Q05683 [Other Products]
UniProt Related Accession #
Q05683[Other Products]
Molecular Weight
65,402 Da[Similar Products]
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NCBI Official Full Name
glutamate decarboxylase 2
NCBI Official Synonym Full Names
glutamate decarboxylase 2
NCBI Official Symbol
Gad2  [Similar Products]
NCBI Official Synonym Symbols
gad65
  [Similar Products]
NCBI Protein Information
glutamate decarboxylase 2; 65 kDa glutamic acid decarboxylase; GAD-65; Glutamate decarboxylase 2 (islet); glutamate decarboxylase 65 kDa isoform; glutamic acid decarboxylase 2; glutamic acid decarboxylase 65
UniProt Protein Name
Glutamate decarboxylase 2
UniProt Synonym Protein Names
65 kDa glutamic acid decarboxylase; GAD-65; Glutamate decarboxylase 65 kDa isoform
Protein Family
Glutamate decarboxylase
UniProt Gene Name
Gad2  [Similar Products]
UniProt Synonym Gene Names
Gad65; GAD-65  [Similar Products]
UniProt Entry Name
DCE2_RAT
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NCBI Summary for Gad2
catalyzes synthesis of gamma-Aminobutyric acid (GABA), the most widely distributed inhibitory neurotransmitter [RGD, Feb 2006]
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UniProt Comments for Gad2
GAD2: Catalyzes the production of GABA. Homodimer. Belongs to the group II decarboxylase family.

Protein type: Other Amino Acids Metabolism - beta-alanine; Carbohydrate Metabolism - butanoate; Amino Acid Metabolism - alanine, aspartate and glutamate; Lyase; EC 4.1.1.15; Other Amino Acids Metabolism - taurine and hypotaurine

Cellular Component: Golgi membrane; presynaptic membrane; synaptic vesicle membrane; perinuclear region of cytoplasm; axon; cytoplasm; synapse; cytoplasmic vesicle; cell junction; cytosol

Molecular Function: glutamate binding; glutamate decarboxylase activity; protein heterodimerization activity; pyridoxal phosphate binding

Biological Process: response to drug; synaptic transmission; glutamate decarboxylation to succinate; neurotransmitter biosynthetic process
Research Articles on Gad2
1. experimental reduction of GAD65/67 expression bilaterally in the NAcbC is sufficient to increase impulsivity in LI rats.
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated withanti-Gad2 antibody
 Reference Product  PubMed Publications
 Abat antibody  >1 publications with Gad2 and Abat
Pathways associated with anti-Gad2 antibody
 Products by Pathway  Pathway Diagram
 Alanine And Aspartate Metabolism Pathway antibodies  Alanine And Aspartate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Biogenic Amine Synthesis Pathway antibodies  Biogenic Amine Synthesis Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 GABA (gamma-Aminobutyrate) Shunt Pathway antibodies  GABA (gamma-Aminobutyrate) Shunt Pathway Diagram
 GABA (gamma-Aminobutyrate) Shunt Pathway antibodies  GABA (gamma-Aminobutyrate) Shunt Pathway Diagram
 GABA Synthesis Pathway antibodies  GABA Synthesis Pathway Diagram
 GABA Synthesis, Release, Reuptake And Degradation Pathway antibodies  GABA Synthesis, Release, Reuptake And Degradation Pathway Diagram
Diseases associated with anti-Gad2 antibody
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >20 publications with Gad2 and Mental Disorders
 Nervous System Diseases Antibodies  >13 publications with Gad2 and Nervous System Diseases
 Brain Diseases Antibodies  >11 publications with Gad2 and Brain Diseases
 Schizophrenia Antibodies  >10 publications with Gad2 and Schizophrenia
 Epilepsy Antibodies  >6 publications with Gad2 and Epilepsy
 Seizures Antibodies  >6 publications with Gad2 and Seizures
 Depressive Disorder Antibodies  >4 publications with Gad2 and Depressive Disorder
 Inflammation Antibodies  >4 publications with Gad2 and Inflammation
 Movement Disorders Antibodies  >2 publications with Gad2 and Movement Disorders
 Substance Withdrawal Syndrome Antibodies  >2 publications with Gad2 and Substance Withdrawal Syndrome
Organs/Tissues associated with anti-Gad2 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >37 publications with Gad2 and Brain
 Mixed Antibodies  >2 publications with Gad2 and Mixed
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