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anti-LMX1B antibody :: Goat LMX1B Polyclonal Antibody

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Catalog # MBS243235
Unit / Price
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  0.05 mg  /  $530 +1 FREE 8GB USB
Immunohistochemistry (IHC)
Product Name

LMX1B, Polyclonal Antibody

Full Product Name

Goat Polyclonal to Human LMX1B

Product Synonym Names
Anti-LMX1B Antibody (Internal) IHC-plus; LMX1B; LMX1.2; NPS1; LIM/homeobox protein 1.2; LMX-1.2; LIM/homeobox protein LMX1B; Human LMX1B
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
phenotype 602575
Clonality
Polyclonal
Host
Goat
Species Reactivity
Gibbon, Chicken, Dog, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Rat
Predicted Reactivity: Xenopus (at least 90% immunogen sequence identity)
Specificity
Human LMX1B.
Purity/Purification
Immunoaffinity Purified
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Concentration
0.5 mg/ml (lot specific)
Target Species
Human
Immunogen Description
Synthetic peptide QQALTTSCYFRDRK from an internal region of human LMX1B (NP_002307.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Dog, Horse, Opossum, Chicken (100%).
Immunogen Type
Synthetic peptide
Immunogen
LMX1B antibody was raised against synthetic peptide QQALTTSCYFRDRK from an internal region of human LMX1B (NP_002307.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Dog, Horse, Opossum, Chicken (100%); Xenopus (93%); Stickleback, Zebrafish (86%).
Antigen Modification
Internal
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Other Notes
Small volumes of anti-LMX1B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-LMX1B antibody
Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
Application Notes for anti-LMX1B antibody
ELISA (1:64000), IHC-P (2.5 - 3.75 ug/ml)
Usage: Peptide ELISA: antibody detection limit dilution 1:64000. Western blot: Preliminary experiments gave an approx 100kDa band in Mouse Kidney lysates after 0.3 ug/ml antibody staining. Please note that currently we cannot find an explanation in the lite...

Immunohistochemistry (IHC) of anti-LMX1B antibody
Anti-LMX1B antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.
anti-LMX1B antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for LMX1B. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
45,080 Da
NCBI Official Full Name
Homo sapiens chromosome 9, GRCh37.p13 Primary Assembly
NCBI Official Synonym Full Names
LIM homeobox transcription factor 1, beta
NCBI Official Symbol
LMX1B  [Similar Products]
NCBI Official Synonym Symbols
NPS1; LMX1.2
  [Similar Products]
NCBI Protein Information
LIM homeobox transcription factor 1-beta; LMX-1.2; LIM/homeobox protein 1.2; LIM/homeobox protein LMX1B
UniProt Protein Name
LIM homeobox transcription factor 1-beta
UniProt Synonym Protein Names
LIM/homeobox protein 1.2; LMX-1.2; LIM/homeobox protein LMX1B
Protein Family
UniProt Gene Name
LMX1B  [Similar Products]
UniProt Synonym Gene Names
LMX-1.2  [Similar Products]
UniProt Entry Name
LMX1B_HUMAN
NCBI Summary for LMX1B
This gene encodes a member of LIM-homeodomain family of proteins containing two N-terminal zinc-binding LIM domains, 1 homeodomain, and a C-terminal glutamine-rich domain. It functions as a transcription factor, and is essential for the normal development of dorsal limb structures, the glomerular basement membrane, the anterior segment of the eye, and dopaminergic and serotonergic neurons. Mutations in this gene are associated with nail-patella syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
UniProt Comments for LMX1B
LMX1B: Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels. Defects in LMX1B are the cause of nail-patella syndrome (NPS); also known as onychoosteodysplasia. NPS is a disease that cause abnormal skeletal patterning and renal dysplasia. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation; DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 9q33.3

Cellular Component: nucleus

Molecular Function: protein binding; zinc ion binding; sequence-specific DNA binding; transcription factor activity

Biological Process: collagen fibril organization; transcription, DNA-dependent; in utero embryonic development; multicellular organismal development; neuron migration; cerebellum morphogenesis; limb morphogenesis; neuron differentiation; organ growth; cell proliferation; dorsal/ventral pattern formation; regulation of transcription, DNA-dependent; midbrain development; positive regulation of transcription from RNA polymerase II promoter; central nervous system neuron development

Disease: Nail-patella Syndrome
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with anti-LMX1B antibody
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