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anti-D5DR antibody :: Rabbit D5DR Polyclonal Antibody

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Catalog # MBS301190
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Immunohistochemistry (IHC)
Product Name

D5DR, Polyclonal Antibody

Popular Item
Also Known As

Rabbit Anti-Human D5DR Polyclonal Antibody

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
477
OMIM
126453
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Predicted Reactivity: Chicken, Dog, Pig, Rabbit
Form/Format
0.1 ml immunogen affinity purified rabbit polyclonal antibody in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
Immunogen
Synthetic peptide corresponding to aa 459-477 of human D5DR.
Control Tissue
Brain
Cellular Localization
Cytoplasm, Membrane
Entrez Gene Code
1816
Pathway
Neuroscience
Preparation and Storage
Store at 2-8 degree C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. There are no definitive signs to indicate instability of this product; therefore, positive and negative controls should be tested simultaneously with unknown specimens. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support.
Other Notes
Small volumes of anti-D5DR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-D5DR antibody
The dopamine receptors are divided into two classes, D1 and D2, which differ in their functional characteristics. D1DR and D5DR compose the D1 class of dopamine receptors, and D2DR, D3DR and D4DR compose the D2 class. D1 receptors stimulate adenylyl cyclase, while D2 receptors inhibit adenylyl cyclase activity.
Applications Tested/Suitable for anti-D5DR antibody
Immunohistochemistry (IHC) Paraffin
Application Notes for anti-D5DR antibody
Immunohistochemistry Procedure
Specimen Preparation: Formalin-fixed, paraffin-embedded tissues are suitable for use with this primary antibody. Deparaffinization: Deparaffinize slides using xylene or xylene alternative and graded alcohols. Antibody Dilution: If using the concentrate format of this product, dilute the antibody 1:50. The dilutions are estimates; actual results may differ because of variability in methods and protocols. Antigen Retrieval: Boil tissue section in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at room temperature for 20 min. Primary Antibody Incubation: Incubate for 30 minutes at room temperature. Slide Washing: Slides must be washed in between steps. Rinse slides with PBS/0.05% Tween. Visualization: Detect the antibody as instructed by the instructions provided with the visualization system.
Immunohistochemistry Dilution: 1:50
IHC Positive Control: Brain

Immunohistochemistry (IHC) of anti-D5DR antibody
Human brain stained with anti-D5DR antibody
anti-D5DR antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for D5DR. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
53 kDa
NCBI Official Full Name
D(1B) dopamine receptor
NCBI Official Synonym Full Names
dopamine receptor D5
NCBI Official Symbol
NCBI Official Synonym Symbols
DBDR; DRD1B; DRD1L2
  [Similar Products]
NCBI Protein Information
D(1B) dopamine receptor; D(1B) dopamine receptor; D1beta dopamine receptor; d(5) dopamine receptor; dopamine D5 receptor; dopamine receptor D1B
UniProt Protein Name
D(1B) dopamine receptor
UniProt Synonym Protein Names
D(5) dopamine receptor; D1beta dopamine receptor; Dopamine D5 receptor
UniProt Gene Name
UniProt Synonym Gene Names
DRD1B; DRD1L2  [Similar Products]
UniProt Entry Name
DRD5_HUMAN
NCBI Summary for D5DR
This gene encodes the D5 subtype of the dopamine receptor. The D5 subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2. [provided by RefSeq, Jul 2008]
UniProt Comments for D5DR
DRD5: Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. Defects in DRD5 are a cause of benign essential blepharospasm (BEB). BEB is a primary focal dystonia affecting the orbicularis oculi muscles. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. BEB usually begins in middle age. Initial symptoms include eye irritation and frequent blinking, progressing to involuntary spasms of eyelid closure. Patients have normal eyes. The visual disturbance is due solely to the forced closure of the eyelids. In severe cases, this can lead to functional blindness. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4p16.1

Cellular Component: brush border membrane; integral to plasma membrane; plasma membrane

Molecular Function: dopamine receptor activity; dopamine binding; dopamine D1 receptor-like receptor activity

Biological Process: synaptic transmission, dopaminergic; wound healing; response to amphetamine; adenylate cyclase activation; transmission of nerve impulse; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure; response to cocaine; G-protein signaling, adenylate cyclase activating pathway; cellular calcium ion homeostasis; synaptic transmission; regulation of female receptivity; regulation of systemic arterial blood pressure by vasopressin; sensitization; negative regulation of blood pressure; positive regulation of adenylate cyclase activity; dopamine receptor, phospholipase C activating pathway; negative regulation of NAD(P)H oxidase activity; associative learning; dopamine receptor, adenylate cyclase activating pathway

Disease: Attention Deficit-hyperactivity Disorder; Blepharospasm, Benign Essential
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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Organs/Tissues associated with anti-D5DR antibody
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