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anti-ASIC1 antibody :: Rabbit ACCN2 Polyclonal Antibody

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Catalog # MBS9208324
Unit / Price
  0.08 mL  /  $150 +1 FREE 8GB USB
  0.4 mL  /  $340 +1 FREE 8GB USB
Product Name

ACCN2 (ASIC1), Polyclonal Antibody

Also Known As

ACCN2 Antibody (C-term)

Product Synonym Names
Acid-sensing ion channel 1; ASIC1; Amiloride-sensitive cation channel 2; neuronal; Brain sodium channel 2; BNaC2; ASIC1; ACCN2; BNAC2
Antibody/Peptide Pairs
ACCN2 peptide (MBS9228112) is used for blocking the activity of ACCN2 antibody (MBS9208324)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
500-526
Immunogen Sequence Length
562
OMIM
602866
3D Structure
ModBase 3D Structure for P78348
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human (Predicted Reactivity: Chicken, Mouse, Rat)
Specificity
This ACCN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 500-526 amino acids from the C-terminal region of human ACCN2.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (lot specific)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-ASIC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ASIC1 antibody
ACCN2 encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member is expressed in most if not all brain neurons, and it may be an ion channel subunit; however, its function as an ion channel remains unknown.
Product Categories/Family for anti-ASIC1 antibody
Applications Tested/Suitable for anti-ASIC1 antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
Application Notes for anti-ASIC1 antibody
WB~~1:1000

Western Blot (WB) of anti-ASIC1 antibody
Western blot analysis of ACCN2 Antibody (C-term) in CEM cell line lysates (35ug/lane). ACCN2 (arrow) was detected using the purified Pab.
anti-ASIC1 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-ASIC1 antibody
Formalin-fixed and paraffin-embedded human brain tissue reacted with ACCN2 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
anti-ASIC1 antibody Immunohistochemistry (IHC) (IHC) image
Flow Cytometry (FC/FACS) of anti-ASIC1 antibody
ACCN2 Antibody (C-term) flow cytometric analysis of CEM cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
anti-ASIC1 antibody Flow Cytometry (FC/FACS) (FC/FACS) image
NCBI/Uniprot data below describe general gene information for ASIC1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
Human (Predicted Reactivity: Chicken, Mouse, Rat)NP_001243759.1; NP_064423.2[Other Products]
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
59909
NCBI Official Full Name
acid-sensing ion channel 1 isoform b
NCBI Official Synonym Full Names
acid sensing (proton gated) ion channel 1
NCBI Official Symbol
ASIC1  [Similar Products]
NCBI Official Synonym Symbols
ASIC; ACCN2; BNaC2
  [Similar Products]
NCBI Protein Information
acid-sensing ion channel 1
UniProt Protein Name
Acid-sensing ion channel 1
UniProt Synonym Protein Names
Amiloride-sensitive cation channel 2, neuronal; Brain sodium channel 2; BNaC2
Protein Family
UniProt Gene Name
ASIC1  [Similar Products]
UniProt Synonym Gene Names
ACCN2; BNAC2; ASIC1; BNaC2  [Similar Products]
UniProt Entry Name
ASIC1_HUMAN
NCBI Summary for ASIC1
This gene encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Members of the ASIC family are sensitive to amiloride and function in neurotransmission. The encoded proteins function in learning, pain transduction, touch sensation, and development of memory and fear. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]
UniProt Comments for ASIC1
ASIC1 iso1: non-voltage-gated amiloride-sensitive cation channel permeable for sodium, potassium and lithium. A member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Expressed in most if not all brain neurons.

Protein type: Transporter; Membrane protein, integral; Channel, cation; Membrane protein, multi-pass; Transporter, ion channel

Chromosomal Location of Human Ortholog: 12q12

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: amiloride-sensitive sodium channel activity; protein binding

Biological Process: transport; calcium ion transport; sodium ion transport; sensory perception of sour taste; signal transduction; transmembrane transport; response to pH
Product References and Citations for anti-ASIC1 antibody
Sherwood,T., et.al., J. Biol. Chem. 284 (41), 27899-27907 (2009)
Kapoor,N., et.al., J. Biol. Chem. 284 (36), 24526-24541 (2009)
Samways,D.S., et.al., Cell Calcium 45 (4), 319-325 (2009)

Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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