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anti-HTR1B antibody :: Rabbit HTR1B / 5-HT2B Receptor Polyclonal Antibody

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Catalog # MBS246779
Unit / Price
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  0.05 mg  /  $530 +1 FREE 8GB USB
Immunohistochemistry (IHC)
Product Name

HTR1B / 5-HT2B Receptor, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal to Human HTR1B / 5-HT2B Receptor

Product Synonym Names
Anti-HTR1B / 5-HT2B Receptor Antibody (Cytoplasmic Domain) IHC-plus; HTR2B; 5-HT 2B receptor; 5HT2B Receptor; 5-HT(2B); 5-HT-2B; 5-HT2b receptor; 5-HT2B; Serotonin 2b receptor; Serotonin 5-HT-2b receptor; Serotonin receptor 2B; Human HTR1B; 5-HT2B Receptor
Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
601122
3D Structure
ModBase 3D Structure for P41595
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Gibbon, Chimpanzee, Gorilla, Human, Monkey, Orangutan
Specificity
Human 5HT2B Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, 0.1% sodium azide.
Concentration
0.7 mg/ml (lot specific)
Target Species
Human
Immunogen Description
Synthetic 17 amino acid peptide from 3rd cytoplasmic domain of human 5HT2B Receptor. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey, Marmoset (100%); Bovine, Rabbit, Pig (88%).
Immunogen Type
Synthetic peptide
Immunogen
HTR1B / 5-HT2B Receptor antibody was raised against synthetic 17 amino acid peptide from 3rd cytoplasmic domain of human 5HT2B Receptor. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey, Marmoset (100%); Bovine, Rabbit, Pig (88%); Dog, Bat, Panda, Horse, Opossum, Stickleback (82%).
Antigen Modification
Cytoplasmic Domain
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Other Notes
Small volumes of anti-HTR1B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-HTR1B antibody
5-HT2B, a Serotonin Receptor, activates phospholipase C upon binding serotonin, which results in a rise in intracellular calcium. It is known that 5-HT2B regulates cardiovascular function during development and in adulthood; mice lacking functional 5-HT2B receptors died of heart defects during gestation or neonatally, and adult mutant mice displayed cardiopathy, including myocyte disarray and ventricular dilation.
Applications Tested/Suitable for anti-HTR1B antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-HTR1B antibody
IHC-P (2 ug/ml)

Immunohistochemistry (IHC) of anti-HTR1B antibody
Anti-5HT2B Receptor antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-HTR1B antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for HTR1B. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
54,298 Da
NCBI Official Full Name
5-hydroxytryptamine receptor 2B
NCBI Official Synonym Full Names
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
NCBI Official Symbol
HTR2B  [Similar Products]
NCBI Official Synonym Symbols
5-HT2B; 5-HT(2B)
  [Similar Products]
NCBI Protein Information
5-hydroxytryptamine receptor 2B; 5-HT-2B; 5-HT 2B receptor; serotonin receptor 2B; 5-hydroxytryptamine 2B receptor; 5-hydroxytryptamine receptor 2B variant b
UniProt Protein Name
5-hydroxytryptamine receptor 2B
UniProt Synonym Protein Names
Serotonin receptor 2B
UniProt Gene Name
HTR2B  [Similar Products]
UniProt Synonym Gene Names
5-HT-2B; 5-HT2B  [Similar Products]
UniProt Entry Name
5HT2B_HUMAN
NCBI Summary for HTR1B
This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. [provided by RefSeq, Oct 2011]
UniProt Comments for HTR1B
5-HT(2B): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Plays a role in the regulation of impulsive behavior. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q36.3-q37.1

Cellular Component: neuron projection; integral to plasma membrane; cytoplasm; plasma membrane; synapse; cell junction

Molecular Function: serotonin binding; serotonin receptor activity; G-protein alpha-subunit binding; drug binding

Biological Process: heart morphogenesis; negative regulation of autophagy; cGMP biosynthetic process; phosphoinositide 3-kinase cascade; intestine smooth muscle contraction; behavior; positive regulation of MAP kinase activity; positive regulation of cell proliferation; protein kinase C activation; neural crest cell differentiation; embryonic morphogenesis; neural crest cell migration; serotonin receptor signaling pathway; regulation of behavior; response to drug; positive regulation of cytokine production; vasoconstriction; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of nitric-oxide synthase activity; calcium-mediated signaling; positive regulation of phosphatidylinositol biosynthetic process; cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; G-protein coupled receptor internalization; phospholipase C activation; positive regulation of cell division; release of sequestered calcium ion into cytosol; positive regulation of endothelial cell proliferation; phosphorylation; negative regulation of apoptosis; positive regulation of cytokine secretion
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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