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anti-PAR2 antibody :: Rabbit PAR2 Polyclonal Antibody

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Catalog # MBS540477
Unit / Price
  0.1 mg Affinity-Purified  /  $390 +1 FREE 8GB USB
Product Name

PAR2, Polyclonal Antibody

Popular Item
Also Known As

PAR2 Antibody

Product Synonym Names
Coagulation factor II receptor like 1; Coagulation factor II thrombin receptor like 1; F2RL1; G protein coupled receptor 11; GPR11; PAR 2; Proteinase activated receptor 2 antibody Thrombin receptor like 1 antibody
Matching Pairs
Antibody: PAR2 (MBS540477)
Positive Control: PAR2 (MBS543040)
Antibody/Peptide Pairs
PAR2 peptide (MBS544118) is used for blocking the activity of PAR2 antibody (MBS540477)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
399
3D Structure
ModBase 3D Structure for P55086
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Chimpanzee, Human, Monkey, Mouse, Rat
Form/Format
Affinity Purified
Concentration
0.68 ug/ul in antibody stabilization buffer (lot specific)
Immunogen
Synthetic peptide taken within amino acid region 347-363 of Mouse PAR2.
Immunoglobulin
IgG
Expression
Expressed in various lymphoid tissues and activated B- and T-lymphocytes, strongly up-regulated in B-cells infected with Epstein-Barr virus and T-cells infected with herpesvirus 6 or 7.
Molecular Function
G-protein coupled receptor, Receptor, Transducer
Structure
Interacts with TLR4, COPS5 and TMED2. Also interacts with GNAQ, GNA11, GNA12, GNA13, and GNA14.
Subcellular Location
Cell membrane; Multi-pass membrane protein
Preparation and Storage
Store at -20°C for long term storage
Other Notes
Small volumes of anti-PAR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PAR2 antibody
Affinity Purified Proteinase-activated receptor 2 Antibody
Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.
Applications Tested/Suitable for anti-PAR2 antibody
ELISA,IHC,IP,WB
Application Notes for anti-PAR2 antibody
ELISA: 1:15,00-1:20,000
Immunocytochemistry: 1:100
Immunofluorescence: 1:100
Immunohistochemistry: 1:100
Immunoprecipitation: 1:200
Western Blot: 1:250

Western Blot (WB) of anti-PAR2 antibody
anti-PAR2 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-PAR2 antibody
anti-PAR2 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-PAR2 antibody
anti-PAR2 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for PAR2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
NCBI Official Full Name
proteinase-activated receptor 2
NCBI Official Synonym Full Names
coagulation factor II (thrombin) receptor-like 1
NCBI Official Symbol
F2rl1  [Similar Products]
NCBI Official Synonym Symbols
Par2; PAR-2; Gpcr11
  [Similar Products]
NCBI Protein Information
proteinase-activated receptor 2
UniProt Protein Name
Proteinase-activated receptor 2
UniProt Synonym Protein Names
Coagulation factor II receptor-like 1; G-protein coupled receptor 11; Thrombin receptor-like 1
Protein Family
UniProt Gene Name
F2rl1  [Similar Products]
UniProt Synonym Gene Names
Gpcr11; Gpr11; Par2; PAR-2  [Similar Products]
UniProt Entry Name
PAR2_MOUSE
UniProt Comments for PAR2
F2RL1: a G-protein coupled receptor for trypsin and trypsin-like enzymes. Acts as a sensor for proteolytic enzymes generated during infection. Modulates pro-inflammatory responses, and innate and adaptive immunity. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. Activates several signaling molecules including phospholipase C (PLC), mitogen-activated protein kinase (MAPK), IKK/NFkB and Rho. Elevates intracellular calcium. Can also be transactivated by cleaved PAR1. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Proposed to have a bronchoprotective role in airway epithelium, but also shown to compromise the airway epithelial barrier by interrupting E-cadherin adhesion. Involved in the regulation of vascular tone; activation results in hypotension presumably mediated by vasodilation. Associates with a subset of G proteins alpha subunits such as G alpha-q, G alpha-11, G alpha-14, G alpha- 12 and G alpha-13, but probably not with G(o) alpha, G(i) subunit alpha-1 and G(i) subunit alpha-2. However, may signal through G(i) subunit alpha. Believed to be a class B receptor that internalizes as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptor, for extended periods of time. Mediates inhibition of TNF-alpha stimulated JNK phosphorylation via coupling to G alpha-q/11; the function involves dissociation of RIPK1 and TRADD from TNFR1. Involved in cellular migration. Involved in cytoskeletal rearrangement and chemotaxis through beta-arrestin-promoted scaffolds; the function is independent of G alpha-q/11 and involves promotion of cofilin dephosphoryltaion and actin filament severing. Induces redistribution of COPS5 from the plasma membrane to the cytosol and activation of the JNK cascade is mediated by COPS5. Involved in the recruitment of leukocytes to the sites of inflammation and is the major PAR receptor capable of modulating eosinophil function such as proinflammatory cytokine secretion, superoxide production and degranulation. During inflammation promotes dendritic cell maturation, trafficking to the lymph nodes and subsequent T-cell activation. Involved in antimicrobial response of innate immune cells; activation enhances phagocytosis of Gram- positive and killing of Gram-negative bacteria. Acts synergistically with interferon-gamma in enhancing antiviral responses. Implicated in a number of acute and chronic inflammatory diseases such as of the joints, lungs, brain, gastrointestinal tract, periodontium, skin, and vascular systems, and in autoimmune disorders. Widely expressed in tissues with especially high levels in pancreas, liver, kidney, small intestine, and colon. Moderate expression is detected in many organs, but none in brain or skeletal muscle. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass

Cellular Component: early endosome; integral to membrane; integral to plasma membrane; membrane; plasma membrane; pseudopodium

Molecular Function: G-protein alpha-subunit binding; G-protein beta-subunit binding; G-protein coupled receptor activity; heterotrimeric G-protein binding; signal transducer activity; thrombin receptor activity

Biological Process: blood coagulation; defense response to virus; elevation of cytosolic calcium ion concentration; G-protein coupled receptor protein signaling pathway; immune system process; inflammatory response; innate immune response; interleukin-1 beta secretion; leukocyte migration; negative regulation of JNK cascade; negative regulation of toll-like receptor 3 signaling pathway; neutrophil activation; positive regulation of actin filament depolymerization; positive regulation of cell migration; positive regulation of chemotaxis; positive regulation of cytokine secretion during immune response; positive regulation of eosinophil degranulation; positive regulation of glomerular filtration; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of JNK cascade; positive regulation of leukocyte chemotaxis; positive regulation of phagocytosis, engulfment; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of positive chemotaxis; positive regulation of pseudopodium formation; positive regulation of Rho protein signal transduction; positive regulation of superoxide release; positive regulation of toll-like receptor 2 signaling pathway; positive regulation of toll-like receptor 3 signaling pathway; positive regulation of toll-like receptor 4 signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of vasodilation; regulation of blood coagulation; regulation of I-kappaB kinase/NF-kappaB cascade; regulation of JNK cascade; signal transduction; T cell activation during immune response
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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