NP_940819
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
brevican core protein isoform 2
NCBI Official Synonym Full Names
brevican
NCBI Official Synonym Symbols
NCBI Protein Information
brevican core protein
UniProt Protein Name
Brevican core protein
UniProt Synonym Protein Names
Brain-enriched hyaluronan-binding protein; BEHAB; Chondroitin sulfate proteoglycan 7
UniProt Synonym Gene Names
UniProt Entry Name
PGCB_HUMAN
NCBI Summary for BCAN
This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. This protein is developmentally regulated and may function in the formation of the brain extracellular matrix. This protein is highly expressed in gliomas and may promote the growth and cell motility of brain tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
UniProt Comments for BCAN
BCAN: May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans. Belongs to the aggrecan/versican proteoglycan family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Membrane protein, GPI anchor; Secreted
Chromosomal Location of Human Ortholog: 1q31
Cellular Component: proteinaceous extracellular matrix; lysosomal lumen; Golgi lumen; extracellular region
Molecular Function: extracellular matrix structural constituent; hyaluronic acid binding; carbohydrate binding
Biological Process: chondroitin sulfate metabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; chondroitin sulfate biosynthetic process; central nervous system development; glycosaminoglycan metabolic process; chondroitin sulfate catabolic process; hippocampus development; carbohydrate metabolic process; pathogenesis; cell adhesion; skeletal development; dermatan sulfate biosynthetic process
Research Articles on BCAN
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Products associated with anti-BCAN antibody
Pathways associated with anti-BCAN antibody
Diseases associated with anti-BCAN antibody
Organs/Tissues associated with anti-BCAN antibody
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