NP_071910.3
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
59,671 Da
NCBI Official Full Name
zinc finger protein Eos
NCBI Official Synonym Full Names
IKAROS family zinc finger 4
NCBI Official Synonym Symbols
NCBI Protein Information
zinc finger protein Eos
UniProt Protein Name
Zinc finger protein Eos
UniProt Synonym Protein Names
Ikaros family zinc finger protein 4
UniProt Synonym Gene Names
UniProt Entry Name
IKZF4_HUMAN
NCBI Summary for IKZF4
Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002]
UniProt Comments for IKZF4
IKZF4: DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Belongs to the Ikaros C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor; DNA-binding; C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: 12q13
Cellular Component: centrosome; nucleoplasm; nucleus
Molecular Function: bHLH transcription factor binding; metal ion binding; protein heterodimerization activity; protein homodimerization activity; sequence-specific DNA binding; transcription factor activity
Biological Process: negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent
Research Articles on IKZF4
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Diseases associated with anti-IKZF4 antibody
Organs/Tissues associated with anti-IKZF4 antibody
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