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anti-ABCC3 antibody :: Goat ABCC3 Polyclonal Antibody

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Catalog # MBS423091
Unit / Price
  0.1 mg  /  $225 +1 FREE 8GB USB
anti-ABCC3 antibody
Product Name

ABCC3, Polyclonal Antibody

Also Known As

Goat anti-ABCC3 Antibody

Product Synonym Names
ABCC3; ATP-binding cassette, sub-family C (CFTR/MRP), member 3; ABC31; DKFZp686E22157; EST90757; MLP2; MOAT-D; MRP3; cMOAT2; ATP-binding cassette sub-family C member 3; canalicular multispecific organic anion transporter 2; canicular multispecific organic; ABCC3 antibody; ATP-binding cassette; sub-family C (CFTR/MRP); member 3 antibody; ABC31 antibody; DKFZp686E22157 antibody; EST90757 antibody; MLP2 antibody; MOAT-D antibody; MRP3 antibody; cMOAT2 antibody; canalicular multispecific organic anion transporter 2 antibody; canicular multispecific organic antibody; ABCC3
Antibody/Peptide Pairs
ABCC3 peptide (MBS427782) is used for blocking the activity of ABCC3 antibody (MBS423091)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
1527
Immunogen Sequence
DTLSNHTDLT DNDP
OMIM
604323
Clonality
Polyclonal
Host
Goat
Species Reactivity
Expected from sequence similarity: Human, Mouse, Dog, Pig, Cow
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence C-DTLSNHTDLTDNDP, from the internal region of the protein sequence according to NP_003777.2.
Epitope
Internal region
Note
This antibody is expected to recognize reported isoform 1 (NP_003777.2;) only.
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-ABCC3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ABCC3 antibody
Peptide ELISA (EIA)
Application Notes for anti-ABCC3 antibody
Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Preliminary experiments in Human, Mouse and Rat Liver lysates gave no specific signal but low background (at antibody concentration up to 1ug/ml).
NCBI/Uniprot data below describe general gene information for ABCC3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
64,632 Da
NCBI Official Full Name
canalicular multispecific organic anion transporter 2 isoform 1
NCBI Official Synonym Full Names
ATP binding cassette subfamily C member 3
NCBI Official Symbol
ABCC3  [Similar Products]
NCBI Official Synonym Symbols
MLP2; MRP3; ABC31; MOAT-D; cMOAT2; EST90757
  [Similar Products]
NCBI Protein Information
canalicular multispecific organic anion transporter 2
UniProt Protein Name
Canalicular multispecific organic anion transporter 2
UniProt Synonym Protein Names
ATP-binding cassette sub-family C member 3; Multi-specific organic anion transporter D; MOAT-D; Multidrug resistance-associated protein 3
Protein Family
UniProt Gene Name
ABCC3  [Similar Products]
UniProt Synonym Gene Names
CMOAT2; MLP2; MRP3; MOAT-D  [Similar Products]
UniProt Entry Name
MRP3_HUMAN
NCBI Summary for ABCC3
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCC3
ABCC3: May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Transporter; Membrane protein, integral; Transporter, ABC family

Chromosomal Location of Human Ortholog: 17q22

Cellular Component: integral to plasma membrane; membrane; plasma membrane

Molecular Function: anion transmembrane-transporting ATPase activity; ATP binding; ATPase activity, coupled to transmembrane movement of substances; bile acid-exporting ATPase activity; organic anion transmembrane transporter activity

Biological Process: bile acid and bile salt transport; metabolic process; transmembrane transport; transport
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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