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anti-AMPD1 antibody :: Goat AMPD1 Polyclonal Antibody

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Catalog # MBS421094
Unit / Price
  0.1 mg  /  $225 +1 FREE 8GB USB
anti-AMPD1 antibody
Product Name

AMPD1, Polyclonal Antibody

Full Product Name

Goat anti-AMPD1 Antibody

Product Synonym Names
AMPD1; adenosine monophosphate deaminase 1 (isoform M); MAD; MADA; Adenosine monophosphate deaminase-1 (muscle); OTTHUMP00000059283; AMPD1 antibody; adenosine monophosphate deaminase 1 (isoform M) antibody; MAD antibody; MADA antibody; Adenosine monophosphate deaminase-1 (muscle) antibody; OTTHUMP00000059283 antibody
Antibody/Peptide Pairs
AMPD1 peptide (MBS425057) is used for blocking the activity of AMPD1 antibody (MBS421094)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
HMFSSKSPKP QE
OMIM
102770
Clonality
Polyclonal
Host
Goat
Species Reactivity
Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow, Pig
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence C-HMFSSKSPKPQE, from the internal region of the protein sequence according to NP_000027.1.
Epitope
Internal region
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-AMPD1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-AMPD1 antibody
Peptide ELISA (EIA)
Application Notes for anti-AMPD1 antibody
Peptide ELISA: Antibody detection limit dilution 1: 1000.
Western Blot: Preliminary experiments in Human Muscle and Rat Muscle lysates gave no specific signal but low background (at antibody concentration up to 1ug/ml).
NCBI/Uniprot data below describe general gene information for AMPD1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
89,763 Da
NCBI Official Full Name
adenosine monophosphate deaminase 1 (isoform M)
NCBI Official Synonym Full Names
adenosine monophosphate deaminase 1
NCBI Official Symbol
AMPD1  [Similar Products]
NCBI Official Synonym Symbols
MAD; MADA; MMDD
  [Similar Products]
NCBI Protein Information
AMP deaminase 1
UniProt Protein Name
AMP deaminase 1
UniProt Synonym Protein Names
AMP deaminase isoform M; Myoadenylate deaminase
Protein Family
UniProt Gene Name
AMPD1  [Similar Products]
UniProt Entry Name
AMPD1_HUMAN
NCBI Summary for AMPD1
Adenosine monophosphate deaminase 1 catalyzes the deamination of AMP to IMP in skeletal muscle and plays an important role in the purine nucleotide cycle. Two other genes have been identified, AMPD2 and AMPD3, for the liver- and erythocyte-specific isoforms, respectively. Deficiency of the muscle-specific enzyme is apparently a common cause of exercise-induced myopathy and probably the most common cause of metabolic myopathy in the human. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]
UniProt Comments for AMPD1
AMPD1: AMP deaminase plays a critical role in energy metabolism. Defects in AMPD1 are the cause of adenosine monophosphate deaminase deficiency muscle type (AMPDDM). AMPDDM is a metabolic disorder resulting in exercise-related myopathy. It is characterized by exercise-induced muscle aches, cramps, and early fatigue. Belongs to the adenosine and AMP deaminases family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleotide Metabolism - purine; Hydrolase; EC 3.5.4.6

Chromosomal Location of Human Ortholog: 1p13

Cellular Component: cytosol

Molecular Function: AMP deaminase activity; metal ion binding; myosin heavy chain binding

Biological Process: IMP salvage; purine salvage; response to organic substance

Disease: Myopathy Due To Myoadenylate Deaminase Deficiency
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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