NP_061968.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
cardiolipin synthase (CMP-forming) isoform 1
NCBI Official Synonym Full Names
cardiolipin synthase 1
NCBI Official Synonym Symbols
CLS; CLS1; GCD10; C20orf155; dJ967N21.6 [Similar Products]
NCBI Protein Information
cardiolipin synthase (CMP-forming)
UniProt Protein Name
Cardiolipin synthase (CMP-forming)
UniProt Synonym Protein Names
Protein GCD10 homolog
UniProt Synonym Gene Names
UniProt Entry Name
CRLS1_HUMAN
NCBI Summary for CRLS1
This gene encodes a member of the CDP-alcohol phosphatidyltransferase class-I family of proteins. The encoded enzyme catalyzes the synthesis of cardiolipin, a phospholipid component of mitochondrial membranes that is critical for mitochondrial function. [provided by RefSeq, Apr 2016]
UniProt Comments for CRLS1
CRLS1: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. Belongs to the CDP-alcohol phosphatidyltransferase class-I family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Lipid Metabolism - glycerophospholipid; Mitochondrial; Membrane protein, integral; Transferase; EC 2.7.8.-; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 20p13-p12.3
Cellular Component: integral to membrane; mitochondrial inner membrane; mitochondrion
Molecular Function: 1-acylglycerol-3-phosphate O-acyltransferase activity; 2-acylglycerol-3-phosphate O-acyltransferase activity; cardiolipin synthase activity; CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity
Biological Process: cardiolipin biosynthetic process
Research Articles on CRLS1
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Pathways associated with anti-CRLS1 antibody
Diseases associated with anti-CRLS1 antibody
Organs/Tissues associated with anti-CRLS1 antibody
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