• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

anti-CITED2 antibody :: Goat CITED2 Polyclonal Antibody

Scan QR to view Datasheet
Catalog # MBS420896
Unit / Price
  0.1 mg  /  $225 +1 FREE 8GB USB
anti-CITED2 antibody
Product Name

CITED2, Polyclonal Antibody

Also Known As

Goat anti-CITED2 (Internal) Antibody

Product Synonym Names
Goat Anti-CITED2 (C Terminus) Antibody; CITED2; Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2; HGNC: 1987; MRG1; P35SRJ; CITED2 antibody; Cbp/p300-interacting transactivator; with Glu/Asp-rich carboxy-terminal domain; 2 antibody; HGNC: 1987 antibody; MRG1 antibody; P35SRJ antibody; CITED2 (Internal)
Antibody/Peptide Pairs
CITED2 peptide (MBS426344) is used for blocking the activity of CITED2 antibody (MBS420896)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
270
Immunogen Sequence
PNVIDTDFID EE
OMIM
602937
Clonality
Polyclonal
Host
Goat
Species Reactivity
Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence C-PNVIDTDFIDEE, from the internal region of the protein sequence according to NP_006070.2.
Epitope
Internal region
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-CITED2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CITED2 antibody
Peptide ELISA (EIA)
Application Notes for anti-CITED2 antibody
Peptide ELISA: Antibody detection limit dilution 1: 4000.
Western Blot: Preliminary experiments in adult human heart, kidney, liver and skin lysates gave no specific signal but low background (at antibody concentration up to 1ug/ml).
NCBI/Uniprot data below describe general gene information for CITED2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
23,732 Da
NCBI Official Full Name
cbp/p300-interacting transactivator 2 isoform 1
NCBI Official Synonym Full Names
Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2
NCBI Official Symbol
CITED2  [Similar Products]
NCBI Official Synonym Symbols
ASD8; MRG1; VSD2; MRG-1; P35SRJ
  [Similar Products]
NCBI Protein Information
cbp/p300-interacting transactivator 2
UniProt Protein Name
Cbp/p300-interacting transactivator 2
UniProt Synonym Protein Names
MSG-related protein 1; MRG-1; P35srj
UniProt Gene Name
CITED2  [Similar Products]
UniProt Synonym Gene Names
MRG1; MRG-1  [Similar Products]
UniProt Entry Name
CITE2_HUMAN
NCBI Summary for CITED2
The protein encoded by this gene inhibits transactivation of HIF1A-induced genes by competing with binding of hypoxia-inducible factor 1-alpha to p300-CH1. Mutations in this gene are a cause of cardiac septal defects. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
UniProt Comments for CITED2
CITED2: Transcriptional coactivator of the p300/CBP-mediated trancription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator- activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left- right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP); stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region. Defects in CITED2 are a cause of ventricular septal defect type 2 (VSD2). VSD2 is a common form of congenital cardiovascular anomaly that may occur alone or in combination with other cardiac malformations. It can affect any portion of the ventricular septum, resulting in abnormal communications between the two lower chambers of the heart. Classification is based on location of the communication, such as perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular defect. Large defects that go unrepaired may give rise to cardiac enlargement, congestive heart failure, pulmonary hypertension, Eisenmenger's syndrome, delayed fetal brain development, arrhythmias, and even sudden cardiac death. Defects in CITED2 are a cause of atrial septal defect type 8 (ASD8). ASD8 is a congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria. Belongs to the CITED family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Cell cycle regulation; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 6q23.3

Cellular Component: nuclear chromatin; nucleus

Molecular Function: chromatin binding; histone acetyltransferase binding; LBD domain binding; protein binding; transcription coactivator activity; transcription corepressor activity; transcription factor activity

Biological Process: cell proliferation; determination of left/right symmetry; heart development; liver development; negative regulation of apoptosis; negative regulation of cell migration; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of cell cycle; positive regulation of cell-cell adhesion; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transforming growth factor beta receptor signaling pathway; response to estrogen stimulus; response to hypoxia; sex determination; spleen development

Disease: Atrial Septal Defect 8; Ventricular Septal Defect 2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000