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anti-SLC6A8 antibody :: Goat Creatine transporter 1/SLC6A8 Polyclonal Antibody

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Catalog # MBS422659
Unit / Price
  0.1 mg  /  $300 +1 FREE 8GB USB
Western Blot (WB)
Product Name

Creatine transporter 1/SLC6A8, Polyclonal Antibody

Also Known As

Goat anti-Creatine transporter 1/SLC6A8 Antibody

Product Synonym Names
SLC6A8; solute carrier family 6 (neurotransmitter transporter, creatine), member 8; CRT; CRTR; CT1; MGC87396; creatine transporter 1; creatine transporter SLC6A8; sodium- and chloride-dependent creatine transporter 1; solute carrier family 6 member 8; SLC6A8 antibody; solute carrier family 6 (neurotransmitter transporter; creatine); member 8 antibody; CRT antibody; CRTR antibody; CT1 antibody; MGC87396 antibody; creatine transporter 1 antibody; creatine transporter SLC6A8 antibody; sodium- and chloride-dependent creatine transporter 1 antibody; Creatine transporter 1; Creatine transporter 1 / SLC6A8
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
635
Immunogen Sequence
ASLANLTCDQ LADRR
OMIM
300036
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Mouse; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence ASLANLTCDQLADRR, from the internal region of the protein sequence according to NP_005620.1; NP_001136277.1; NP_001136278.1.
Epitope
Internal region
Note
This antibody is expected to recognize all reported isoforms (NP_005620.1; NP_001136277.1; NP_001136278.1).
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-SLC6A8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-SLC6A8 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-SLC6A8 antibody
Peptide ELISA: Antibody detection limit dilution 1: 8000.
Western Blot: Approx 70kDa band observed in Mouse Heart, Kidney and Skeletal Muscle lysates (calculated MW of 71. 0kDa according to Mouse NP_598748.1). Recommended concentration: 0.1-0.3ug/ml.

Western Blot (WB) of anti-SLC6A8 antibody
(0.1ug/ml) staining of Mouse Heart lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-SLC6A8 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for SLC6A8. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
Manufactured in an ISO 9001:2015 Certified Laboratory.NP_001136277.1; NP_001136278.1[Other Products]
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
58,453 Da
NCBI Official Full Name
sodium- and chloride-dependent creatine transporter 1 isoform 1
NCBI Official Synonym Full Names
solute carrier family 6 member 8
NCBI Official Symbol
SLC6A8  [Similar Products]
NCBI Official Synonym Symbols
CRT; CT1; CRTR; CTR5; CCDS1
  [Similar Products]
NCBI Protein Information
sodium- and chloride-dependent creatine transporter 1
UniProt Protein Name
Sodium- and chloride-dependent creatine transporter 1
UniProt Synonym Protein Names
Solute carrier family 6 member 8
UniProt Gene Name
SLC6A8  [Similar Products]
UniProt Synonym Gene Names
CT1; Creatine transporter 1  [Similar Products]
UniProt Entry Name
SC6A8_HUMAN
NCBI Summary for SLC6A8
The protein encoded by this gene is a plasma membrane protein whose function is to transport creatine into and out of cells. Defects in this gene can result in X-linked creatine deficiency syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
UniProt Comments for SLC6A8
SLC6A8: Required for the uptake of creatine in muscles and brain. Defects in SLC6A8 are the cause of X-linked creatine deficiency syndrome (XL-CDS). XL-CDS causes developmental delay, hypotonia, mental retardation, seizures, short stature and midface hypoplasia. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A8 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Transporter, SLC family; Motility/polarity/chemotaxis; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: integral to membrane; integral to plasma membrane; plasma membrane

Molecular Function: creatine transporter activity; creatine:sodium symporter activity; neurotransmitter:sodium symporter activity

Biological Process: creatine metabolic process; creatine transport; muscle contraction; neurotransmitter transport; sodium ion transport; transport

Disease: Cerebral Creatine Deficiency Syndrome 1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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