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anti-FNBP1 antibody :: Goat FBP17/FNBP1 Polyclonal Antibody

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Catalog # MBS420283
Unit / Price
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  0.1 mg  /  $300 +1 FREE 8GB USB
Western Blot (WB)
Product Name

FBP17/FNBP1, Polyclonal Antibody

Popular Item
Full Product Name

Goat anti-FBP17/FNBP1 Antibody

Product Synonym Names
FNBP1; FBP17; KIAA0554; formin binding protein 1; formin-binding protein 17; MGC126804; FNBP1 antibody; FBP17 antibody; KIAA0554 antibody; formin binding protein 1 antibody; formin-binding protein 17 antibody; MGC126804 antibody; FBP17 / FNBP1
Product Synonym Gene Name
Antibody/Peptide Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
KQLESSKRRF ERDC
OMIM
606191
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence KQLESSKRRFERDC, from the internal region of the protein sequence according to NP_055848.1.
Epitope
Internal region
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-FNBP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-FNBP1 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-FNBP1 antibody
Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Approx 70kDa band observed in human testis lysates (calculated MW of 71.3kDa according to NP_055848.1). Recommended concentration: 0.25-2ug/ml.

Western Blot (WB) of anti-FNBP1 antibody
Staining (0.25ug/ml) of human testis lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
anti-FNBP1 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for FNBP1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
70,752 Da
NCBI Official Full Name
formin-binding protein 1
NCBI Official Synonym Full Names
formin binding protein 1
NCBI Official Symbol
FNBP1  [Similar Products]
NCBI Official Synonym Symbols
FBP17
  [Similar Products]
NCBI Protein Information
formin-binding protein 1
UniProt Protein Name
Formin-binding protein 1
UniProt Synonym Protein Names
Formin-binding protein 17; hFBP17
Protein Family
UniProt Gene Name
FNBP1  [Similar Products]
UniProt Synonym Gene Names
FBP17; KIAA0554; hFBP17  [Similar Products]
UniProt Entry Name
FNBP1_HUMAN
NCBI Summary for FNBP1
The protein encoded by this gene is a member of the formin-binding-protein family. The protein contains an N-terminal Fer/Cdc42-interacting protein 4 (CIP4) homology (FCH) domain followed by a coiled-coil domain, a proline-rich motif, a second coiled-coil domain, a Rho family protein-binding domain (RBD), and a C-terminal SH3 domain. This protein binds sorting nexin 2 (SNX2), tankyrase (TNKS), and dynamin; an interaction between this protein and formin has not been demonstrated yet in human. [provided by RefSeq, Jul 2008]
UniProt Comments for FNBP1
FNBP1: May act as a link between RND2 signaling and regulation of the actin cytoskeleton. Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL. A chromosomal aberration involving FNBP1 is found in acute leukemias. Translocation t(9;11)(q34;q23) with MLL. The relatively low incidence of the MLL-FNBP1 fusion protein in acute leukemia may reflect the marginal capacity of this fusion protein to induce cellular transformation. Belongs to the FNBP1 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Actin-binding; Vesicle

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: cell cortex; coated pit; cytoplasmic membrane-bound vesicle; cytoskeleton; lysosome; plasma membrane; trans-Golgi network

Molecular Function: ARF guanyl-nucleotide exchange factor activity; identical protein binding; lipid binding; protein binding

Biological Process: endocytosis; positive regulation of GTPase activity; vesicle-mediated transport
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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