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anti-FOXP2 antibody :: Goat FOXP2 Polyclonal Antibody

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Catalog # MBS421233
Unit / Price
  0.1 mg  /  $300 +1 FREE 8GB USB
Western Blot (WB)
Product Name

FOXP2, Polyclonal Antibody

Also Known As

Goat anti-FOXP2 (C terminus) Antibody

Product Synonym Names
Goat Anti-FOXP2 (internal) Antibody; FOXP2; forkhead box P2; SPCH1; CAGH44; TNRC10; CAG repeat protein 44; speech and language disorder 1; trinucleotide repeat containing 10; forkhead/winged-helix transcription factor; DKFZp686H1726; OTTHUMP00000196932; FOXP2 antibody; forkhead box P2 antibody; SPCH1 antibody; CAGH44 antibody; TNRC10 antibody; CAG repeat protein 44 antibody; speech and language disorder 1 antibody; trinucleotide repeat containing 10 antibody; forkhead/winged-helix transcription factor antibody; DKFZp686H1726 antibody; OTTHUMP00000196932 antibody; FOXP2 (C terminus)
Antibody/Peptide Pairs
FOXP2 peptide (MBS428462) is used for blocking the activity of FOXP2 antibody (MBS421233)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
715
Immunogen Sequence
REIEEEPLSE DLE
OMIM
602081
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human, Mouse; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow etc
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence C-REIEEEPLSEDLE, from the C Terminus of the protein sequence according to NP_055306.1; NP_683696.2; NP_683697.1.
Epitope
C Terminus
Note
This antibody is expected to recognise all three reported isoforms (NP_055306.1; NP_683696.2; NP_683697.1).
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-FOXP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-FOXP2 antibody
Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-FOXP2 antibody
Peptide ELISA: Antibody detection limit dilution 1: 32000.
Immunohistochemistry: An anonymous customer found positive results in IHC on Mouse embryonic spinal cord.
Western Blot: Approx 80kDa band observed in human brain (cerebellum) lysates (calculated MW of 79.9kDa according to NP_055306.1). Recommended concentration: 0.5-1.5ug/ml.

Western Blot (WB) of anti-FOXP2 antibody
(0.5ug/ml) staining of human cerebellum lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-FOXP2 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for FOXP2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
Manufactured in an ISO 9001:2015 Certified Laboratory.NP_683696.2; NP_683697.1[Other Products]
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
81,840 Da
NCBI Official Full Name
forkhead box protein P2 isoform I
NCBI Official Synonym Full Names
forkhead box P2
NCBI Official Symbol
FOXP2  [Similar Products]
NCBI Official Synonym Symbols
SPCH1; CAGH44; TNRC10
  [Similar Products]
NCBI Protein Information
forkhead box protein P2
UniProt Protein Name
Forkhead box protein P2
UniProt Synonym Protein Names
CAG repeat protein 44; Trinucleotide repeat-containing gene 10 protein
Protein Family
UniProt Gene Name
FOXP2  [Similar Products]
UniProt Synonym Gene Names
CAGH44; TNRC10  [Similar Products]
UniProt Entry Name
FOXP2_HUMAN
NCBI Summary for FOXP2
This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]
UniProt Comments for FOXP2
FOXP2: Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Involved in neural mechanisms mediating the development of speech and language. Forms homodimers and heterodimers with FOXP1 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1. Isoform 1 and isoform 6 are expressed in adult and fetal brain, caudate nucleus and lung. 9 isoforms of the human protein are produced by alternative splicing.

Protein type: C2H2-type zinc finger protein; DNA-binding

Chromosomal Location of Human Ortholog: 7q31

Cellular Component: nucleus

Molecular Function: DNA binding; metal ion binding; protein binding; protein heterodimerization activity; protein homodimerization activity; sequence-specific DNA binding; transcription factor activity

Biological Process: alveolus development; camera-type eye development; caudate nucleus development; cerebellum development; cerebral cortex development; growth; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of mesenchymal cell proliferation; post-embryonic development; putamen development; righting reflex; skeletal muscle development; smooth muscle development; transcription, DNA-dependent; vocal learning

Disease: Speech-language Disorder 1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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