NP_062815.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43,186 Da
NCBI Official Full Name
transient receptor potential cation channel subfamily V member 5
NCBI Official Synonym Full Names
transient receptor potential cation channel subfamily V member 5
NCBI Protein Information
transient receptor potential cation channel subfamily V member 5
UniProt Protein Name
Transient receptor potential cation channel subfamily V member 5
UniProt Synonym Protein Names
Calcium transport protein 2; CaT2; Epithelial calcium channel 1; ECaC; ECaC1; Osm-9-like TRP channel 3; OTRPC3
UniProt Synonym Gene Names
UniProt Entry Name
TRPV5_HUMAN
NCBI Summary for TRPV5
This gene is a member of the transient receptor family and the TrpV subfamily. The calcium-selective channel encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level. [provided by RefSeq, Jul 2008]
UniProt Comments for TRPV5
TRPV5: Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)- dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV5 sub-subfamily.
Protein type: Motility/polarity/chemotaxis; Membrane protein, multi-pass; Channel, cation; Membrane protein, integral
Chromosomal Location of Human Ortholog: 7q35
Cellular Component: apical plasma membrane; integral to plasma membrane; plasma membrane
Molecular Function: calcium channel activity; calmodulin binding; protein binding
Biological Process: calcium ion transport; protein tetramerization
Research Articles on TRPV5
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Products associated with anti-TRPV5 antibody
Pathways associated with anti-TRPV5 antibody
Diseases associated with anti-TRPV5 antibody
Organs/Tissues associated with anti-TRPV5 antibody
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