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anti-VDAC2 antibody :: Goat VDAC2 Polyclonal Antibody

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Catalog # MBS420094
Unit / Price
  0.1 mg  /  $300 +1 FREE 8GB USB
Western Blot (WB)
Product Name

VDAC2, Polyclonal Antibody

Popular Item
Full Product Name

Goat anti-VDAC2 (C Terminus) Antibody

Product Synonym Names
Goat Anti-VDAC2 (Internal) Antibody; VDAC2; voltage-dependent anion channel 2; RP11-375G3.1; FLJ23841; VDAC2 antibody; voltage-dependent anion channel 2 antibody; RP11-375G3.1 antibody; FLJ23841 antibody; VDAC2 (C Terminus)
Antibody/Peptide Pairs
VDAC2 peptide (MBS428292) is used for blocking the activity of VDAC2 antibody (MBS420094)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
GHKVGLALEL EA
OMIM
193245
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human, Rat; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig, Cow
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence C-GHKVGLALELEA, from the C Terminus of the protein sequence according to NP_003366.2.
Epitope
C Terminus
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-VDAC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-VDAC2 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-VDAC2 antibody
Peptide ELISA: Antibody detection limit dilution 1: 4000.
Western Blot: Approx 30kDa band observed in Human Brain (Cerebellum) and Rat Brain lysates (calculated MW of 31.6kDa according to NP_003366.2). Recommended concentration: 1-3ug/ml.

Western Blot (WB) of anti-VDAC2 antibody
(1ug/ml) staining of Human Brain (Cerebellum) lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-VDAC2 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for VDAC2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
30,412 Da
NCBI Official Full Name
voltage-dependent anion-selective channel protein 2 isoform 2
NCBI Official Synonym Full Names
voltage dependent anion channel 2
NCBI Official Symbol
VDAC2  [Similar Products]
NCBI Official Synonym Symbols
NCBI Protein Information
voltage-dependent anion-selective channel protein 2
UniProt Protein Name
Voltage-dependent anion-selective channel protein 2
UniProt Synonym Protein Names
Outer mitochondrial membrane protein porin 2
UniProt Gene Name
VDAC2  [Similar Products]
UniProt Synonym Gene Names
VDAC-2; hVDAC2  [Similar Products]
UniProt Entry Name
VDAC2_HUMAN
NCBI Summary for VDAC2
This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
UniProt Comments for VDAC2
VDAC2: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation- selective. Interacts with hexokinases. Expressed in all tissues examined. Belongs to the eukaryotic mitochondrial porin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; Channel, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 10q22

Cellular Component: lipid raft; mitochondrial inner membrane; mitochondrial outer membrane; mitochondrion; myelin sheath; nucleus; pore complex; synaptic vesicle

Molecular Function: nucleotide binding; porin activity; protein binding; voltage-gated anion channel activity

Biological Process: anion transport; negative regulation of protein polymerization; transmembrane transport
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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