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anti-EIF2B4 antibody :: Goat EIF2B4 Polyclonal Antibody

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Catalog # MBS422421
Unit / Price
  0.1 mg  /  $300 +1 FREE 8GB USB
Western Blot (WB)
Product Name

EIF2B4, Polyclonal Antibody

Full Product Name

Goat anti-EIF2B4 Antibody

Product Synonym Names
EIF2B4; eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa; DKFZp586J0119; EIF-2B; EIF2B; EIF2Bdelta; eIF-2B GDP-GTP exchange factor subunit delta; eukaryotic translation initiation factor 2B, subunit 4 delta; translation initiation facto; DKFZp586J0119 antibody; EIF2B antibody; EIF-2B antibody; eIF-2B GDP-GTP exchange factor subunit delta antibody; EIF2Bdelta antibody; eukaryotic translation initiation factor 2B; subunit 4 delta antibody; eukaryotic translation initiation factor 2B; subunit 4 delta; 67kDa antibody; translation initiation facto antibody; EIF2B4 antibody
Antibody/Peptide Pairs
EIF2B4 peptide (MBS427285) is used for blocking the activity of EIF2B4 antibody (MBS422421)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
RKDYGSKVSL FSH
OMIM
603896
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow, Rabbit
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence C-RKDYGSKVSLFSH, from the internal region of the protein sequence according to NP_751945.2; NP_001029288.1; NP_056451.3.
Epitope
Internal region
Note
This antibody is expected to recognize all reported isoforms (NP_751945.2; NP_001029288.1; NP_056451.3).
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-EIF2B4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-EIF2B4 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-EIF2B4 antibody
Peptide ELISA: Antibody detection limit dilution 1: 16000.

Western Blot (WB) of anti-EIF2B4 antibody
(0.3ug/ml) staining of K562 lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-EIF2B4 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for EIF2B4. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
Manufactured in an ISO 9001:2015 Certified Laboratory.NP_001029288.1; NP_056451.3[Other Products]
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
57,458 Da
NCBI Official Full Name
translation initiation factor eIF-2B subunit delta isoform 1
NCBI Official Synonym Full Names
eukaryotic translation initiation factor 2B subunit delta
NCBI Official Symbol
EIF2B4  [Similar Products]
NCBI Official Synonym Symbols
EIF2B; EIF-2B; EIF2Bdelta
  [Similar Products]
NCBI Protein Information
translation initiation factor eIF-2B subunit delta
UniProt Protein Name
Translation initiation factor eIF-2B subunit delta
UniProt Synonym Protein Names
eIF-2B GDP-GTP exchange factor subunit delta
UniProt Gene Name
EIF2B4  [Similar Products]
UniProt Synonym Gene Names
EIF2BD  [Similar Products]
UniProt Entry Name
EI2BD_HUMAN
NCBI Summary for EIF2B4
Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta, subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for EIF2B4
eIF2B-delta: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Defects in EIF2B4 are a cause of leukodystrophy with vanishing white matter (VWM). VWM is a leukodystrophy that occurs mainly in children. Neurological signs include progressive cerebellar ataxia, spasticity, inconstant optic atrophy and relatively preserved mental abilities. The disease is chronic-progressive with, in most individuals, additional episodes of rapid deterioration following febrile infections or minor head trauma. While childhood onset is the most common form of the disorder, some severe forms are apparent at birth. A severe, early-onset form seen among the Cree and Chippewayan populations of Quebec and Manitoba is called Cree leukoencephalopathy. Milder forms may not become evident until adolescence or adulthood. Some females with milder forms of the disease who survive to adolescence exhibit ovarian dysfunction. This variant of the disorder is called ovarioleukodystrophy. Belongs to the eIF-2B alpha/beta/delta subunits family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Translation initiation; Motility/polarity/chemotaxis; Translation

Chromosomal Location of Human Ortholog: 2p23.3

Cellular Component: cytoplasm; cytosol; eukaryotic translation initiation factor 2B complex

Molecular Function: guanyl-nucleotide exchange factor activity; protein binding; S-methyl-5-thioribose-1-phosphate isomerase activity; translation initiation factor activity; translation initiation factor binding

Biological Process: cellular response to stimulus; methionine salvage; myelination; negative regulation of translation initiation in response to stress; negative regulation of translational initiation; oligodendrocyte development; ovarian follicle development; positive regulation of GTPase activity; regulation of translation; response to glucose stimulus; response to heat; response to peptide hormone stimulus; translational initiation

Disease: Leukoencephalopathy With Vanishing White Matter
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with anti-EIF2B4 antibody
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