NP_003816.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
17,789 Da
NCBI Official Full Name
synaptosomal-associated protein 23 isoform SNAP23A
NCBI Official Synonym Full Names
synaptosome associated protein 23kDa
NCBI Official Synonym Symbols
SNAP-23; SNAP23A; SNAP23B; HsT17016 [Similar Products]
NCBI Protein Information
synaptosomal-associated protein 23
UniProt Protein Name
Synaptosomal-associated protein 23
UniProt Synonym Protein Names
Vesicle-membrane fusion protein SNAP-23
UniProt Synonym Gene Names
UniProt Entry Name
SNP23_HUMAN
NCBI Summary for SNAP23
Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for SNAP23
SNAP23: a member of the SNAP-25 family of SNARE proteins. Structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternatively spliced isoforms have been described.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 15q14
Cellular Component: azurophil granule; cytoplasm; focal adhesion; mast cell granule; neuron projection; nucleoplasm; plasma membrane; SNARE complex; specific granule
Molecular Function: protein binding; SNAP receptor activity; syntaxin binding
Biological Process: histamine secretion by mast cell; post-Golgi vesicle-mediated transport; protein transport; synaptic vesicle fusion to presynaptic membrane; synaptic vesicle priming; vesicle targeting
Research Articles on SNAP23
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Products associated with anti-SNAP23 antibody
Pathways associated with anti-SNAP23 antibody
Diseases associated with anti-SNAP23 antibody
Organs/Tissues associated with anti-SNAP23 antibody
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