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anti-ABCE1 antibody :: Goat ABCE1/RNase L Polyclonal Antibody

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Catalog # MBS422004
Unit / Price
  0.1 mg  /  $225 +1 FREE 8GB USB
anti-ABCE1 antibody
Product Name

ABCE1/RNase L, Polyclonal Antibody

Also Known As

Goat anti-ABCE1/RNase L Antibody

Product Synonym Names
Goat Anti-ABCE1/ RNAse L inhibitor Antibody; ABCE1; ATP-binding cassette, sub-family E (OABP), member 1; ABC38; OABP; RLI; RNASEL1; RNASELI; RNS4I; ATP-binding cassette, sub-family E, member 1; RNase L inhibitor; ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) inhibitor; ABCE1 antibody; ATP-binding cassette; sub-family E (OABP); member 1 antibody; ABC38 antibody; OABP antibody; RLI antibody; RNASEL1 antibody; RNASELI antibody; RNS4I antibody; ATP-binding cassette; sub-family E; member 1 antibody; RNase L inhibitor antibody; ribonuclease L (2\1; 5\1-oligoisoadenylate synthetase-dependent) inhibitor antibody; ABCE1 / RNase L
Product Synonym Gene Name
Antibody/Peptide Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
599
Immunogen Sequence
NHDKCKPKKC RQEC
OMIM
601213
Clonality
Polyclonal
Host
Goat
Species Reactivity
Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence NHDKCKPKKCRQEC, from the N Terminus of the protein sequence according to NP_002931.2; NP_001035809.1.
Epitope
N Terminus
Note
Reported variants represent identical protein: NP_002931.2 NP_001035809.1
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-ABCE1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ABCE1 antibody
Peptide ELISA (EIA)
Application Notes for anti-ABCE1 antibody
Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Preliminary experiments gave an approx.80kDa band in Human Spleen lysates after 0.2ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 67.3kDa according to NP_002931.2. The ~80kDa band was successfully blocked by incubation with the immunizing peptide.
NCBI/Uniprot data below describe general gene information for ABCE1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
Manufactured in an ISO 9001:2015 Certified Laboratory.NP_001035809.1[Other Products]
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
67,314 Da
NCBI Official Full Name
ATP-binding cassette sub-family E member 1
NCBI Official Synonym Full Names
ATP binding cassette subfamily E member 1
NCBI Official Symbol
ABCE1  [Similar Products]
NCBI Official Synonym Symbols
RLI; OABP; ABC38; RNS4I; RNASEL1; RNASELI
  [Similar Products]
NCBI Protein Information
ATP-binding cassette sub-family E member 1
UniProt Protein Name
ATP-binding cassette sub-family E member 1
UniProt Synonym Protein Names
2'-5'-oligoadenylate-binding protein; HuHP68; RNase L inhibitor; Ribonuclease 4 inhibitor; RNS4I
Protein Family
UniProt Gene Name
ABCE1  [Similar Products]
UniProt Synonym Gene Names
RLI; RNASEL1; RNASELI; RNS4I; RNS4I  [Similar Products]
UniProt Entry Name
ABCE1_HUMAN
NCBI Summary for ABCE1
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCE1
ABCE1: Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly. Belongs to the ABC transporter superfamily. ABCE family.

Chromosomal Location of Human Ortholog: 4q31

Cellular Component: cytoplasm; membrane; mitochondrial matrix; mitochondrion

Molecular Function: ATP binding; ATPase activity; protein binding; ribonuclease inhibitor activity

Biological Process: negative regulation of catalytic activity; response to virus; RNA catabolic process; transmembrane transport; viral reproduction
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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