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anti-TDGF1 antibody :: Goat CRIPTO Polyclonal Antibody

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Catalog # MBS421778
Unit / Price
  0.1 mg  /  $300 +1 FREE 8GB USB
Immunohistochemistry (IHC)
Product Name

CRIPTO (TDGF1), Polyclonal Antibody

Also Known As

Goat anti-CRIPTO Antibody

Product Synonym Names
TDGF1; teratocarcinoma-derived growth factor 1; CR; CRGF; CRIPTO; Cripto-1; -; TDGF1 antibody; teratocarcinoma-derived growth factor 1 antibody; CR antibody; CRGF antibody; CRIPTO antibody; Cripto-1 antibody
Product Synonym Gene Name
Antibody/Peptide Pairs
CRIPTO peptide (MBS425217) is used for blocking the activity of CRIPTO antibody (MBS421778)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
188
Immunogen Sequence
YGRNCEHDVR KEN
OMIM
187395
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence YGRNCEHDVRKEN, from the internal region of the protein sequence according to NP_003203.1.
Epitope
Internal region
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-TDGF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-TDGF1 antibody
Peptide ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-TDGF1 antibody
Peptide ELISA: Antibody detection limit dilution 1: 128000.
Immunohistochemistry: In paraffin embedded Human Placenta shows stainng assocated with nuclei in some trophoblasts and weak cytoplasm staining in cytotrophoblasts. Recommended concentration, 3-5ug/ml.

Immunohistochemistry (IHC) of anti-TDGF1 antibody
(3.8ug/ml) staining of paraffin embedded Human Placenta. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
anti-TDGF1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for TDGF1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,169 Da
NCBI Official Full Name
teratocarcinoma-derived growth factor 1 isoform 1
NCBI Official Synonym Full Names
teratocarcinoma-derived growth factor 1
NCBI Official Symbol
TDGF1  [Similar Products]
NCBI Official Synonym Symbols
CR; CRGF; CRIPTO
  [Similar Products]
NCBI Protein Information
teratocarcinoma-derived growth factor 1
UniProt Protein Name
Teratocarcinoma-derived growth factor 1
UniProt Synonym Protein Names
Cripto-1 growth factor; CRGF; Epidermal growth factor-like cripto protein CR1
UniProt Gene Name
TDGF1  [Similar Products]
UniProt Synonym Gene Names
CRIPTO; CRGF  [Similar Products]
UniProt Entry Name
TDGF1_HUMAN
NCBI Summary for TDGF1
This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
UniProt Comments for TDGF1
TDGF1: Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm. Interacts with the activin type-1 receptor ACVR1B. Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung.

Protein type: Cell cycle regulation; Membrane protein, GPI anchor; Membrane protein, peripheral; Cell adhesion; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: apical plasma membrane; cell surface; extracellular space; extrinsic to plasma membrane; lipid raft; plasma membrane

Molecular Function: growth factor activity; protein binding; receptor binding

Biological Process: activation of MAPK activity; cell differentiation; cell migration during sprouting angiogenesis; determination of anterior/posterior axis, embryo; embryonic development; epidermal growth factor receptor signaling pathway; heart development; mammary gland development; morphogenesis of a branching structure; negative regulation of apoptosis; peptidyl-serine phosphorylation; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; regulation of signal transduction; somatic stem cell maintenance
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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