NP_009138.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
16,110 Da
NCBI Official Full Name
dual specificity protein phosphatase 10
NCBI Official Synonym Full Names
dual specificity phosphatase 10
NCBI Official Synonym Symbols
NCBI Protein Information
dual specificity protein phosphatase 10
UniProt Protein Name
Dual specificity protein phosphatase 10
UniProt Synonym Protein Names
Mitogen-activated protein kinase phosphatase 5; MAP kinase phosphatase 5; MKP-5
UniProt Synonym Gene Names
UniProt Entry Name
DUS10_HUMAN
NCBI Summary for DUSP10
Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
UniProt Comments for DUSP10
MKP-5: a non-receptor, dual-specificity phosphoprotein phosphatase (DUSP). Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP10 binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene. Contains 1 rhodanese domain.
Protein type: Motility/polarity/chemotaxis; EC 3.1.3.16; Protein phosphatase, dual-specificity; EC 3.1.3.48
Chromosomal Location of Human Ortholog: 1q41
Cellular Component: cytoplasm; Golgi apparatus; nucleoplasm; nucleus
Molecular Function: MAP kinase phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; phosphoprotein phosphatase activity; phosphoric monoester hydrolase activity; protein tyrosine phosphatase activity
Biological Process: inactivation of MAPK activity; JNK cascade; negative regulation of JNK activity; negative regulation of oligodendrocyte differentiation; oligodendrocyte differentiation; protein amino acid dephosphorylation; regulation of adaptive immune response; response to lipopolysaccharide; response to stress
Research Articles on DUSP10
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-DUSP10 antibody
Pathways associated with anti-DUSP10 antibody
Diseases associated with anti-DUSP10 antibody
Organs/Tissues associated with anti-DUSP10 antibody
|