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anti-ITPR3 antibody :: Goat ITPR3 Polyclonal Antibody

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Catalog # MBS420457
Unit / Price
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  0.1 mg  /  $225 +1 FREE 8GB USB
anti-ITPR3 antibody
Product Name

ITPR3, Polyclonal Antibody

Popular Item
Full Product Name

Goat anti-ITPR3 Antibody

Product Synonym Names
ITPR3; inositol 1,4,5-triphosphate receptor, type 3; HGNC: 6182; FLJ36205; IP3R; IP3R3; ITPR3 antibody; inositol 1; 4; 5-triphosphate receptor; type 3 antibody; HGNC: 6182 antibody; FLJ36205 antibody; IP3R antibody; IP3R3 antibody
Antibody/Peptide Pairs
ITPR3 peptide (MBS425319) is used for blocking the activity of ITPR3 antibody (MBS420457)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
DKKERPTDEE GFLH
OMIM
147267
Clonality
Polyclonal
Host
Goat
Species Reactivity
Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Immunogen
Peptide with sequence C-DKKERPTDEEGFLH, from the internal region of the protein sequence according to NP_002215.2.
Epitope
Internal region
Note
No cross-reactivity expected with other types of ITPR
Preparation and Storage
Aliquot and store at -20°C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-ITPR3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms forITPR3purchase
ITPG3 protein acts as both an inositol trisphosphate receptor and a calcium channel critical to transduction pathways and calcium signaling pathway. Pubmed publication ITPR3 searches implicate inositol 1 4 5 trisphosphate and type 3 1 4 5 triphosphate receptor in multiple disorders diseases domains, making ITPR3 gene product a translational target for drugs compounds expression modifications research. The goat anti ITPR3 polyclonal type antibody allows flexible methologies, including WB or ELISA development for a wide range of species proteins, including human mouse rat and rabbit. This ITPR3 antibody is derived from a fusion peptide and affinity purified, reacts to most common secondary antibodies, such as rabbit IgG Alexa fluor conjugates to goat or chemical substrates like AMP. 1 publication ITPR3 details a calculated 304kD for cell lysates, but these products recognize a 60kD band by WB, which is competed by peptide control to trisphosphate receptor type 3.
Applications Tested/Suitable for anti-ITPR3 antibody
Peptide ELISA (EIA)
Application Notes for anti-ITPR3 antibody
Peptide ELISA: Antibody detection limit dilution 1: 128000.

Western Blot: Preliminary experiments gave an approx 60kDa band in Human Adipose, Colon, Duodenum, Heart and Liver lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 304kDa according to NP_002215.1. The 60kDa band was successfully blocked by incubation with the immunizing peptide.
NCBI/Uniprot data below describe general gene information for ITPR3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
inositol 1,4,5-trisphosphate receptor type 3
NCBI Official Synonym Full Names
inositol 1,4,5-trisphosphate receptor type 3
NCBI Official Symbol
ITPR3  [Similar Products]
NCBI Official Synonym Symbols
IP3R; IP3R3
  [Similar Products]
NCBI Protein Information
inositol 1,4,5-trisphosphate receptor type 3
UniProt Protein Name
Inositol 1,4,5-trisphosphate receptor type 3
UniProt Synonym Protein Names
IP3 receptor isoform 3; IP3R 3; InsP3R3; Type 3 inositol 1,4,5-trisphosphate receptor; Type 3 InsP3 receptor
UniProt Gene Name
ITPR3  [Similar Products]
UniProt Synonym Gene Names
IP3R 3; InsP3R3; Type 3 InsP3 receptor  [Similar Products]
UniProt Entry Name
ITPR3_HUMAN
NCBI Summary for ITPR3
This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010]
UniProt Comments for ITPR3
IP3R3: a multi-pass endoplasmic reticulum membrane receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. Expressed in intestinal crypt and villus epithelial cells. The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. Phosphorylated on tyrosine residues. Phosphorylated by AKT1 on serine and/or threonine residues. Belongs to the InsP3 receptor family.

Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Channel, calcium

Chromosomal Location of Human Ortholog: 6p21

Cellular Component: apical part of cell; brush border; cell soma; cytoplasm; cytosol; dendrite; endoplasmic reticulum; endoplasmic reticulum membrane; integral to plasma membrane; membrane; myelin sheath; nuclear outer membrane; nucleolus; nucleoplasm; perinuclear region of cytoplasm; plasma membrane; receptor complex

Molecular Function: calcium ion binding; calcium-release channel activity; inositol 1,3,4,5 tetrakisphosphate binding; inositol 1,4,5-triphosphate-sensitive calcium-release channel activity; inositol hexakisphosphate binding; phosphoinositide binding; protein binding

Biological Process: elevation of cytosolic calcium ion concentration; G-protein coupled receptor protein signaling pathway; inositol phosphate-mediated signaling; memory; platelet activation; protein heterooligomerization; protein homooligomerization; regulation of insulin secretion; release of sequestered calcium ion into cytosol; response to calcium ion; sensory perception of bitter taste; sensory perception of sweet taste; sensory perception of umami taste

Disease: Diabetes Mellitus, Insulin-dependent
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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