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anti-NGFR antibody :: Goat NGFR Polyclonal Antibody

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Catalog # MBS421194
Unit / Price
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  0.1 mg  /  $300 +1 FREE 8GB USB
Western Blot (WB)
Product Name

NGFR, Polyclonal Antibody

Popular Item
Full Product Name

Goat anti-NGFR Antibody

Product Synonym Names
Goat Anti-p75NTR / CD271 (aa202-215) Antibody; NGFR; nerve growth factor receptor (TNFR superfamily, member 16); HGNC: 7809; TNFRSF16; p75(NTR); p75NTR; CD271; Gp80-LNGFR; low affinity nerve growth factor receptor; low-affinity nerve growth factor receptor; nerve growth factor receptor; NGFR antibody; nerve growth factor receptor (TNFR superfamily; member 16) antibody; HGNC: 7809 antibody; TNFRSF16 antibody; p75(NTR) antibody; p75NTR antibody; CD271 antibody; low affinity nerve growth factor receptor antibody; low-affinity nerve growth factor receptor antibody; Gp80-LNGFR antibody; nerve growth factor receptor antibody
Antibody/Peptide Pairs
NGFR peptide (MBS428590) is used for blocking the activity of NGFR antibody (MBS421194)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
AKREEVEKLL NG
OMIM
162010
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Immunogen
Peptide with sequence C-AKREEVEKLLNG, from the internal region of the protein sequence according to NP_002498.1
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-NGFR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-NGFR antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-NGFR antibody
Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Approx 75kDa band observed in Human Duodenum and Human Heart lysates (calculated MW of 45.2kDa according to NP_4804). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Nykjaer et al, Curr Opin Neurobiol.2005 Feb;15(1): 49-57). Recommended concentration: 0.3-1ug/ml.

Western Blot (WB) of anti-NGFR antibody
(0.3ug/ml) staining of Human Heart lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-NGFR antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for NGFR. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
35,767 Da
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 16
NCBI Official Synonym Full Names
nerve growth factor receptor
NCBI Official Symbol
NCBI Official Synonym Symbols
CD271; p75NTR; TNFRSF16; p75(NTR); Gp80-LNGFR
  [Similar Products]
NCBI Protein Information
tumor necrosis factor receptor superfamily member 16
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 16
UniProt Synonym Protein Names
Gp80-LNGFR; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; NGF receptor; p75 ICD; CD_antigen: CD271
UniProt Gene Name
UniProt Synonym Gene Names
TNFRSF16; NGF receptor  [Similar Products]
UniProt Entry Name
TNR16_HUMAN
NCBI Summary for NGFR
Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008]
UniProt Comments for NGFR
NGFR: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Homodimer; disulfide-linked. Interacts with p75NTR- associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1. Interacts with NTRK2; may regulate the ligand specificity of the NTRK2 receptor. Interacts with LINGO1.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 17q21-q22

Cellular Component: cell surface; clathrin-coated endocytic vesicle; cytosol; endosome; external side of plasma membrane; extracellular region; Golgi apparatus; integral to plasma membrane; lipid raft; neuron projection; nuclear envelope; nucleoplasm; nucleus; perikaryon; plasma membrane; rough endoplasmic reticulum

Molecular Function: beta-amyloid binding; nerve growth factor binding; neurotrophin TRKA receptor binding; protein binding; Rab GTPase binding; receptor activity; signal transducer activity; transmembrane receptor activity; tumor necrosis factor receptor activity; ubiquitin protein ligase binding

Biological Process: axon guidance; caspase activation; circadian regulation of gene expression; glucose homeostasis; immune response; inflammatory response; intracellular protein transport; membrane protein intracellular domain proteolysis; negative regulation of apoptosis; negative regulation of axonogenesis; negative regulation of caspase activity; negative regulation of mitochondrial depolarization; negative regulation of neuron apoptosis; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; positive regulation of axonogenesis; positive regulation of MAPKKK cascade; positive regulation of myelination; positive regulation of protein kinase B signaling cascade; positive regulation of Rho protein signal transduction; positive regulation of synaptic transmission, cholinergic; positive regulation of synaptic transmission, glutamatergic; regulation of apoptosis; regulation of caspase activity; regulation of cell proliferation; response to lipopolysaccharide; response to wounding; sensory perception of pain; tumor necrosis factor-mediated signaling pathway
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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