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anti-CRHR1 antibody :: Goat CRHR1/CRF-R Polyclonal Antibody

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Catalog # MBS421140
Unit / Price
  0.1 mg  /  $300 +1 FREE 8GB USB
anti-CRHR1 antibody
Product Name

CRHR1/CRF-R, Polyclonal Antibody

Also Known As

Goat anti-CRHR1/CRF-R (aa 250 - 263) Antibody

Product Synonym Names
Goat Anti-CRHR1 / CRF-R (aa 107 - 117) Antibody; CRHR1; CRF-R; corticotropin releasing hormone receptor 1; CRF1; CRFR1; CRH-R1h; CRHR; CRHR1f; corticotropin releasing hormone receptor variant 1h; seven transmembrane helix receptor; CRHR1 antibody; CRF-R antibody; corticotropin releasing hormone receptor 1 antibody; CRF1 antibody; CRFR1 antibody; CRH-R1h antibody; CRHR antibody; CRHR1f antibody; corticotropin releasing hormone receptor variant 1h antibody; seven transmembrane helix receptor antibody; CRHR1 / CRF-R (aa 250 - 263)
Product Synonym Gene Name
Antibody/Peptide Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
415
Immunogen Sequence
KLYYDNEKCW FGKR
OMIM
122561
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Mouse; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow, Sheep
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence KLYYDNEKCWFGKR, from the internal region of the protein sequence according to NP_004373.2.
Epitope
Internal region
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-CRHR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CRHR1 antibody
Peptide ELISA (EIA), Immunofluorescence (IF), Immunohistochemistry (IHC)
Application Notes for anti-CRHR1 antibody
Peptide ELISA: Antibody detection limit dilution 1: 16000.
Immunohistochemistry: This product is successfully used in immunohistochemistry on mouse brain.
Western Blot: Preliminary experiments in human colon, duodenum and placenta lysates gave no specific signal but low background (at antibody concentration up to 1ug/ml).
Immunofluorescence: This product is successfully used in immunofluoresence on mouse brain.
NCBI/Uniprot data below describe general gene information for CRHR1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
28,122 Da
NCBI Official Full Name
corticotropin-releasing factor receptor 1 isoform 2
NCBI Official Synonym Full Names
corticotropin releasing hormone receptor 1
NCBI Official Symbol
CRHR1  [Similar Products]
NCBI Official Synonym Symbols
CRF1; CRHR; CRF-R; CRFR1; CRF-R1; CRFR-1; CRH-R1; CRHR1L; CRF-R-1; CRH-R-1
  [Similar Products]
NCBI Protein Information
corticotropin-releasing factor receptor 1
UniProt Protein Name
Corticotropin-releasing factor receptor 1
UniProt Synonym Protein Names
Corticotropin-releasing hormone receptor 1; CRH-R-1; CRH-R1
UniProt Gene Name
CRHR1  [Similar Products]
UniProt Synonym Gene Names
CRFR; CRFR1; CRHR; CRF-R-1; CRF-R1; CRFR-1; CRH-R-1; CRH-R1  [Similar Products]
UniProt Entry Name
CRFR1_HUMAN
NCBI Summary for CRHR1
This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants. Readthrough transcription also exists between this gene and upstream GeneID:401884 (ADP-ribosylation factor 3 pseudogene), and the readthrough transcripts encode isoforms that share similarity with the products of this gene. [provided by RefSeq, Dec 2014]
UniProt Comments for CRHR1
CRF-R1: a G-protein coupled receptor that specifically binds corticotropin-releasing hormone, a potent mediator of endocrine, autonomic, behavioral, and immune responses to stress. Four splice-variant isoforms have been described.

Protein type: Receptor, GPCR; GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 17q21.31

Cellular Component: endosome; integral to membrane; integral to plasma membrane; intrinsic to plasma membrane; plasma membrane

Molecular Function: corticotrophin-releasing factor receptor activity; protein binding

Biological Process: adenylate cyclase activation; adrenocorticotropin hormone secretion; cell surface receptor linked signal transduction; female pregnancy; immune response; parturition
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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