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anti-BCAP31 antibody :: Goat BCAP31/BAP31 Polyclonal Antibody

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Catalog # MBS420668
Unit / Price
  0.1 mg  /  $300 +1 FREE 8GB USB
Western Blot (WB)
Product Name

BCAP31/BAP31, Polyclonal Antibody

Also Known As

Goat anti-BCAP31/BAP31 Antibody

Product Synonym Names
BCAP31; BAP31; DXS1357E; accessory protein BAP31; CDM; 6C6-AG; B-cell receptor-associated protein 31; CDM; 6C6 antigen; BCR-associated protein Bap31; OTTHUMP00000025978; p28 Bap31; BCAP31 antibody; BAP31 antibody; DXS1357E antibody; accessory protein BAP31 antibody; CDM antibody; 6C6-AG antibody; B-cell receptor-associated protein 31 antibody; CDM antibody; 6C6 antigen antibody; BCR-associated protein Bap31 antibody; OTTHUMP00000025978 antibody; p28 Bap31 antibody; BCAP31 / BAP31
Product Synonym Gene Name
Antibody/Peptide Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
313
Immunogen Sequence
QAAVDGPMDK KEE
OMIM
300398
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human, Dog, Pig, Cow
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence C-QAAVDGPMDKKEE, from the C Terminus of the protein sequence according to NP_001132929.1; NP_005736.3.
Epitope
C Terminus
Note
This antibody is expected to recognise isoform a (NP_001132929.1) and isoform b (NP_005736.3; NP_001132913.1).
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-BCAP31 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-BCAP31 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-BCAP31 antibody
Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Approx 30kDa band observed in Human Placenta and Brain lysate (predicted MW of 28kDa according to NP_005736). Recommended for use at 1-3ug/ml.

Western Blot (WB) of anti-BCAP31 antibody
(0.1ug/ml) staining of Human Breast lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. chemiluminescence.
anti-BCAP31 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for BCAP31. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
Manufactured in an ISO 9001:2015 Certified Laboratory.NP_005736.3[Other Products]
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
34,752 Da
NCBI Official Full Name
B-cell receptor-associated protein 31 isoform a
NCBI Official Synonym Full Names
B-cell receptor-associated protein 31
NCBI Official Symbol
BCAP31  [Similar Products]
NCBI Official Synonym Symbols
CDM; DDCH; BAP31; 6C6-AG; DXS1357E
  [Similar Products]
NCBI Protein Information
B-cell receptor-associated protein 31
UniProt Protein Name
B-cell receptor-associated protein 31
UniProt Synonym Protein Names
6C6-AG tumor-associated antigen; Protein CDM; p28
UniProt Gene Name
BCAP31  [Similar Products]
UniProt Synonym Gene Names
BAP31; DXS1357E; BCR-associated protein 31; Bap31  [Similar Products]
UniProt Entry Name
BAP31_HUMAN
NCBI Summary for BCAP31
This gene encodes a member of the B-cell receptor associated protein 31 superfamily. The encoded protein is a multi-pass transmembrane protein of the endoplasmic reticulum that is involved in the anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi and in caspase 8-mediated apoptosis. Microdeletions in this gene are associated with contiguous ABCD1/DXS1375E deletion syndrome (CADDS), a neonatal disorder. Alternative splicing of this gene results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 16. [provided by RefSeq, Jan 2012]
UniProt Comments for BCAP31
BCAP31 iso2: May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis. Homodimer and heterodimer with BCAP29. Binds CASP8 (isoform 9) as a complex containing BCAP31, BCAP29, BCL2 and/or BCL2L1. Interacts with VAMP3, VAMP1 and membrane IgD immunoglobulins. May interact with ACTG1 and non-muscle myosin II. Interacts with PTPLB. Ubiquitous. Belongs to the BCAP29/BCAP31 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; integral to plasma membrane; lipid particle; membrane; translocon complex

Molecular Function: protein binding

Biological Process: antigen processing and presentation of peptide antigen via MHC class I; cell structure disassembly during apoptosis; elevation of cytosolic calcium ion concentration; elevation of mitochondrial calcium ion concentration; ER to Golgi vesicle-mediated transport; positive regulation of caspase activity; reduction of endoplasmic reticulum calcium ion concentration

Disease: Deafness, Dystonia, And Cerebral Hypomyelination
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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