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anti-PTGS2 antibody :: Goat COX2/PTGS2 Polyclonal Antibody

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Catalog # MBS421257
Unit / Price
  0.1 mg  /  $300 +1 FREE 8GB USB
Western Blot (WB)
Product Name

COX2/PTGS2, Polyclonal Antibody

Popular Item
Also Known As

Goat anti-COX2/PTGS2 Antibody

Product Synonym Names
PTGS2; COX2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase); COX-2; PHS-2; PGG/HS; PGHS-2; hCox-2; prostaglandin G/H synthase and cyclooxygenase; GRIPGHS; cyclooxygenase 2b; PTGS2 antibody; COX2 antibody; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) antibody; COX-2 antibody; PHS-2 antibody; PGG/HS antibody; PGHS-2 antibody; hCox-2 antibody; prostaglandin G/H synthase and cyclooxygenase antibody; GRIPGHS antibody; cyclooxygenase 2b antibody; COX2 / PTGS2
Product Synonym Gene Name
Antibody/Peptide Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
604
Immunogen Sequence
NPTVLLKERS TEL
OMIM
600262
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human, Dog, Pig, Cow
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence C-NPTVLLKERSTEL, from the C Terminus of the protein sequence according to NP_000954.1.
Epitope
C Terminus
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-1745
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-PTGS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-PTGS2 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-PTGS2 antibody
Peptide ELISA: Antibody detection limit dilution 1: 32000.
Western Blot: Approx 70-75kDa band observed in H460 lysates (predicted MW of 69kDa according to NP_000954.1). Recommended for use at 0.5-2ug/ml.

Western Blot (WB) of anti-PTGS2 antibody
Staining (0.5ug/ml) of H460 lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
anti-PTGS2 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for PTGS2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
68,996 Da
NCBI Official Full Name
prostaglandin G/H synthase 2
NCBI Official Synonym Full Names
prostaglandin-endoperoxide synthase 2
NCBI Official Symbol
PTGS2  [Similar Products]
NCBI Official Synonym Symbols
COX2; COX-2; PHS-2; PGG/HS; PGHS-2; hCox-2; GRIPGHS
  [Similar Products]
NCBI Protein Information
prostaglandin G/H synthase 2
UniProt Protein Name
Prostaglandin G/H synthase 2
UniProt Synonym Protein Names
Cyclooxygenase-2; COX-2; PHS II; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; Prostaglandin-endoperoxide synthase 2
UniProt Gene Name
PTGS2  [Similar Products]
UniProt Synonym Gene Names
COX2; COX-2; PGH synthase 2; PGHS-2  [Similar Products]
UniProt Entry Name
PGH2_HUMAN
NCBI Summary for PTGS2
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009]
UniProt Comments for PTGS2
COX-2: Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity. Homodimer. Belongs to the prostaglandin G/H synthase family.

Protein type: Oxidoreductase; Lipid Metabolism - arachidonic acid; EC 1.14.99.1

Chromosomal Location of Human Ortholog: 1q25.2-q25.3

Cellular Component: caveola; cytoplasm; endoplasmic reticulum; endoplasmic reticulum lumen; endoplasmic reticulum membrane; neuron projection; nucleus; protein complex

Molecular Function: arachidonate 15-lipoxygenase activity; enzyme binding; heme binding; lipid binding; metal ion binding; peroxidase activity; prostaglandin-endoperoxide synthase activity; protein binding; protein homodimerization activity

Biological Process: angiogenesis; bone mineralization; brown fat cell differentiation; cell motility; cyclooxygenase pathway; decidualization; embryo implantation; hair cycle; inflammatory response; learning; lipoxygenase pathway; memory; negative regulation of calcium ion transport; negative regulation of cell cycle; negative regulation of cell proliferation; negative regulation of smooth muscle contraction; negative regulation of synaptic transmission, dopaminergic; nicotinamide metabolic process; ovulation; positive regulation of apoptosis; positive regulation of fever; positive regulation of NF-kappaB import into nucleus; positive regulation of nitric oxide biosynthetic process; positive regulation of prostaglandin biosynthetic process; positive regulation of smooth muscle cell proliferation; positive regulation of smooth muscle contraction; positive regulation of synaptic plasticity; positive regulation of synaptic transmission, glutamatergic; positive regulation of vasoconstriction; prostaglandin biosynthetic process; prostaglandin metabolic process; regulation of blood pressure; regulation of inflammatory response; response to drug; response to estradiol stimulus; response to fructose stimulus; response to glucocorticoid stimulus; response to lipopolysaccharide; response to lithium ion; response to manganese ion; response to oxidative stress; response to vitamin D; sensory perception of pain
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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