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anti-INO80 antibody :: Goat INO80 Polyclonal Antibody

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Catalog # MBS422086
Unit / Price
  0.1 mg  /  $225 +1 FREE 8GB USB
anti-INO80 antibody
Product Name

INO80, Polyclonal Antibody

Also Known As

Goat anti-INO80 Antibody

Product Synonym Names
INO80; INO80 homolog (S. cerevisiae); INO80A; INOC1; hINO80; INO80 complex homolog 1; INO80 complex subunit A; homolog of yeast INO80; INO80 antibody; INO80 homolog (S. cerevisiae) antibody; INO80A antibody; INOC1 antibody; hINO80 antibody; INO80 complex homolog 1 antibody; INO80 complex subunit A antibody; homolog of yeast INO80 antibody; INO80
Antibody/Peptide Pairs
INO80 peptide (MBS425092) is used for blocking the activity of INO80 antibody (MBS422086)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
1556
Immunogen Sequence
TQEDYDSNHF KAQ
OMIM
610169
Clonality
Polyclonal
Host
Goat
Species Reactivity
Expected from sequence similarity: Human, Rat Dog, Cow
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence C-TQEDYDSNHFKAQ, from the internal region of the protein sequence according to NP_060023.1.
Epitope
Internal region
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-INO80 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-INO80 antibody
Peptide ELISA (EIA)
Application Notes for anti-INO80 antibody
Peptide ELISA: Antibody detection limit dilution 1: 4000.
Western Blot: Preliminary experiments in Human Brain (Cerebellum) and Human Testis lysates and in lysates of cell lines HeLa and K562 gave no specific signal but low background (at antibody concentration up to 1ug/ml).
NCBI/Uniprot data below describe general gene information for INO80. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
176,753 Da
NCBI Official Full Name
DNA helicase INO80
NCBI Official Synonym Full Names
INO80 complex subunit
NCBI Official Symbol
INO80  [Similar Products]
NCBI Official Synonym Symbols
INOC1; INO80A; hINO80
  [Similar Products]
NCBI Protein Information
DNA helicase INO80
UniProt Protein Name
DNA helicase INO80
UniProt Synonym Protein Names
INO80 complex subunit A; Putative DNA helicase INO80 complex homolog 1
Protein Family
UniProt Gene Name
INO80  [Similar Products]
UniProt Synonym Gene Names
INO80A; INOC1; KIAA1259; hINO80  [Similar Products]
UniProt Entry Name
INO80_HUMAN
NCBI Summary for INO80
This gene encodes a subunit of the chromatin remodeling complex, which is classified into subfamilies depending on sequence features apart from the conserved ATPase domain. This protein is the catalytic ATPase subunit of the INO80 chromatin remodeling complex, which is characterized by a DNA-binding domain. This protein is proposed to bind DNA and be recruited by the YY1 transcription factor to activate certain genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
UniProt Comments for INO80
INOC1: DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed:20687897 the contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segregation during normal cell division cycle. Belongs to the SNF2/RAD54 helicase family.

Protein type: EC 3.6.4.12; Helicase; DNA-binding

Chromosomal Location of Human Ortholog: 15q15.1

Cellular Component: microtubule; nucleus

Molecular Function: actin binding; alpha-tubulin binding; ATP binding; ATPase activity; DNA binding; DNA helicase activity; protein binding

Biological Process: cell division; chromatin remodeling; DNA duplex unwinding; double-strand break repair; double-strand break repair via homologous recombination; mitotic sister chromatid segregation; positive regulation of cell growth; positive regulation of transcription from RNA polymerase II promoter; spindle assembly; transcription, DNA-dependent
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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