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anti-CPEB1 antibody :: Goat CPEB1 Polyclonal Antibody

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Catalog # MBS420722
Unit / Price
  0.1 mg  /  $300 +1 FREE 8GB USB
Western Blot (WB)
Product Name

CPEB1, Polyclonal Antibody

Also Known As

Goat anti-CPEB1 Antibody

Product Synonym Names
CPEB1; CPEB; FLJ13203; cytoplasmic polyadenylation element binding protein 1; CEBP; CPE-BP1; MGC34136; MGC60106; CPE-binding protein 1; CPEB1 antibody; CPEB antibody; FLJ13203 antibody; cytoplasmic polyadenylation element binding protein 1 antibody; CEBP antibody; CPE-BP1 antibody; MGC34136 antibody; MGC60106 antibody; CPE-binding protein 1 antibody
Antibody/Peptide Pairs
CPEB1 peptide (MBS425647) is used for blocking the activity of CPEB1 antibody (MBS420722)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
561
Immunogen Sequence
PLMRNQKNRD SS
OMIM
607342
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human, Cow
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence C-PLMRNQKNRDSS, from the C Terminus of the protein sequence according to NP_085097.3; NP_001073001.1; NP_001073002.1; NP_001073003.1.
Epitope
C Terminus
Note
This antibody is expected to recognise alle reported isoforms. Variants (NP_001073002.1; NP_001073003.1) encode the same isoform.
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-CPEB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CPEB1 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-CPEB1 antibody
Peptide ELISA: Antibody detection limit dilution 1: 128000.
Western Blot: Approx 65-70kDa band observed in human brain lysates (predicted MW of 65kDa according to NP_085097). Recommended for use at 0.5-2ug/ml. Please note this band was always accompanied by a slightly stonger band at approx 48kDa and further both bands could be blocked by incubation with the immunising peptide.

Western Blot (WB) of anti-CPEB1 antibody
Staining (0.5ug/ml) of human brain lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
anti-CPEB1 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for CPEB1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
Manufactured in an ISO 9001:2015 Certified Laboratory.NP_001073001.1; NP_001073002.1; NP_001073003.1[Other Products]
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
53,635 Da
NCBI Official Full Name
cytoplasmic polyadenylation element-binding protein 1 isoform 1
NCBI Official Synonym Full Names
cytoplasmic polyadenylation element binding protein 1
NCBI Official Symbol
CPEB1  [Similar Products]
NCBI Official Synonym Symbols
CPEB; CPEB-1; h-CPEB; CPE-BP1; hCPEB-1
  [Similar Products]
NCBI Protein Information
cytoplasmic polyadenylation element-binding protein 1
UniProt Protein Name
Cytoplasmic polyadenylation element-binding protein 1
UniProt Gene Name
CPEB1  [Similar Products]
UniProt Synonym Gene Names
CPEB; CPE-BP1; CPE-binding protein 1; h-CPEB; hCPEB-1  [Similar Products]
UniProt Entry Name
CPEB1_HUMAN
NCBI Summary for CPEB1
This gene encodes a member of the cytoplasmic polyadenylation element binding protein family. This highly conserved protein binds to a specific RNA sequence, called the cytoplasmic polyadenylation element, found in the 3' untranslated region of some mRNAs. The encoded protein functions in both the cytoplasm and the nucleus. It is involved in the regulation of mRNA translation, as well as processing of the 3' untranslated region, and may play a role in cell proliferation and tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
UniProt Comments for CPEB1
CPEB: cytoplasmic polyadenylation element binding protein 1. Binds to the protein CPE and drives its polyadenylation. Activated by the protein kinase AurA. Insulin and progesterone stimulate AurA-catalyzed phosphorylation of CPEB in oocytes. Neuronal CPEB regulates local protein synthesis and stabilizes synapse-specific long-term facilitation in aplysia.

Protein type: Translation; RNA-binding

Chromosomal Location of Human Ortholog: 15q25.2

Cellular Component: cell junction; cell soma; centrosome; cytoplasm; dendrite; growth cone; neuron projection; nucleoplasm; nucleus; perinuclear region of cytoplasm; postsynaptic density; postsynaptic membrane; synapse

Molecular Function: metal ion binding; mRNA 3'-UTR binding; nucleotide binding; ribosome binding; translation factor activity, nucleic acid binding; translation repressor activity, nucleic acid binding

Biological Process: cellular response to insulin stimulus; mRNA processing; mRNA transport; negative regulation of cell proliferation; positive regulation of cell migration; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of translation; translation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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