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anti-NTF3 antibody :: Goat Neurotrophin 3 Polyclonal Antibody

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Catalog # MBS421732
Unit / Price
  0.1 mg  /  $225 +1 FREE 8GB USB
anti-NTF3 antibody
Product Name

Neurotrophin 3 (NTF3), Polyclonal Antibody

Full Product Name

Goat anti-Neurotrophin 3 Antibody

Product Synonym Names
NTF3; neurotrophin 3; HDNF; MGC129711; NGF-2; NGF2; NT3; NTF3 antibody; neurotrophin 3 antibody; HDNF antibody; MGC129711 antibody; NGF-2 antibody; NGF2 antibody; NT3 antibody; Neurotrophin 3; Neurotrophin 3
Antibody/Peptide Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
TSRRKRYAEH KSH
OMIM
162660
Clonality
Polyclonal
Host
Goat
Species Reactivity
Expected from sequence similarity: Human, Cow
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence C-TSRRKRYAEHKSH, from the internal region of the protein sequence according to NP_001096124.1; NP_002518.1.
Epitope
Internal region
Note
This antibody is expected to recognise both isoforms (NP_001096124.1; NP_002518.1)
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-NTF3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-NTF3 antibody
Peptide ELISA (EIA)
Application Notes for anti-NTF3 antibody
Peptide ELISA: Antibody detection limit dilution 1: 1000.
Western Blot: Preliminary experiments in Human Brain (Cerebellum and Hippocampus) lysates gave no specific signal but low background (at antibody concentration up to 2ug/ml).
NCBI/Uniprot data below describe general gene information for NTF3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
Manufactured in an ISO 9001:2015 Certified Laboratory.NP_002518.1[Other Products]
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
30,800 Da
NCBI Official Full Name
neurotrophin-3 isoform 1 preproprotein
NCBI Official Synonym Full Names
neurotrophin 3
NCBI Official Symbol
NCBI Official Synonym Symbols
NT3; HDNF; NGF2; NT-3; NGF-2
  [Similar Products]
NCBI Protein Information
neurotrophin-3
UniProt Protein Name
Neurotrophin-3
UniProt Synonym Protein Names
HDNF; Nerve growth factor 2; NGF-2; Neurotrophic factor
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
NT-3; NGF-2  [Similar Products]
UniProt Entry Name
NTF3_HUMAN
NCBI Summary for NTF3
The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008]
UniProt Comments for NTF3
NT-3: Seems to promote the survival of visceral and proprioceptive sensory neurons. Belongs to the NGF-beta family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted; Cytokine

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: cytoplasmic membrane-bound vesicle; extracellular region

Molecular Function: chemoattractant activity; growth factor activity; nerve growth factor binding; neurotrophin p75 receptor binding; protein binding; receptor binding

Biological Process: activation of MAPK activity; activation of protein kinase B; cell-cell signaling; induction of positive chemotaxis; myelination; negative regulation of neuron apoptosis; negative regulation of peptidyl-tyrosine phosphorylation; nervous system development; neurite morphogenesis; positive chemotaxis; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of glial cell differentiation; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of receptor internalization; regulation of apoptosis; regulation of neuron differentiation; regulation of synaptic transmission; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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