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anti-TUSC3 antibody :: Goat TUSC3/N33 Polyclonal Antibody

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Catalog # MBS421607
Unit / Price
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  0.1 mg  /  $300 +1 FREE 8GB USB
Western Blot (WB)
Product Name

TUSC3/N33, Polyclonal Antibody

Full Product Name

Goat anti-TUSC3/N33 Antibody

Product Synonym Names
TUSC3; tumor suppressor candidate 3; D8S1992; MGC13453; N33; OST3A; Putative prostate cancer tumor suppressor; TUSC3 antibody; tumor suppressor candidate 3 antibody; D8S1992 antibody; MGC13453 antibody; N33 antibody; OST3A antibody; Putative prostate cancer tumor suppressor antibody; TUSC3 / N33
Product Synonym Gene Name
Antibody/Peptide Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
PQRQCSVCRQ AN
OMIM
601385
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Cow
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence PQRQCSVCRQAN, from the internal region of the protein sequence according to NP_006756.2; NP_839952.1.
Epitope
Internal region
Note
This antibody is expected to recognise both reported isoforms (NP_006756.2; NP_839952.1).
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-TUSC3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-TUSC3 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-TUSC3 antibody
Peptide ELISA: Antibody detection limit dilution 1: 1000.

Western Blot (WB) of anti-TUSC3 antibody
(1ug/ml) staining of Human Liver lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-TUSC3 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for TUSC3. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
Manufactured in an ISO 9001:2008 Certified Laboratory.NP_839952.1[Other Products]
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,558 Da
NCBI Official Full Name
tumor suppressor candidate 3 isoform a
NCBI Official Synonym Full Names
tumor suppressor candidate 3
NCBI Official Symbol
TUSC3  [Similar Products]
NCBI Official Synonym Symbols
M33; N33; MRT7; MRT22; OST3A; D8S1992
  [Similar Products]
NCBI Protein Information
tumor suppressor candidate 3
UniProt Protein Name
Tumor suppressor candidate 3
UniProt Synonym Protein Names
Magnesium uptake/transporter TUSC3; Protein N33
UniProt Gene Name
TUSC3  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
TUSC3_HUMAN
NCBI Summary for TUSC3
This gene is a candidate tumor suppressor gene. It is located within a homozygously deleted region of a metastatic prostate cancer. The gene is expressed in most nonlymphoid human tissues including prostate, lung, liver, and colon. Expression was also detected in many epithelial tumor cell lines. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for TUSC3
TUSC3: Magnesium transporter. May be involved in N- glycosylation through its association with N-oligosaccharyl transferase. Defects in TUSC3 are the cause of mental retardation autosomal recessive type 7 (MRT7); also known as mental retardation non-syndromic autosomal recessive 7. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non- syndromic mental retardation patients do not manifest other clinical signs. Belongs to the OST3/OST6 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 8p22

Cellular Component: endoplasmic reticulum membrane; integral to plasma membrane; mitochondrion; oligosaccharyl transferase complex; plasma membrane

Molecular Function: dolichyl-diphosphooligosaccharide-protein glycotransferase activity; magnesium ion transmembrane transporter activity

Biological Process: cognition; magnesium ion transport; protein amino acid N-linked glycosylation; protein amino acid N-linked glycosylation via asparagine; transmembrane transport

Disease: Mental Retardation, Autosomal Recessive 7
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Organs/Tissues associated with anti-TUSC3 antibody
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