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anti-NKX2-1 antibody :: Rabbit NKX2-1 Polyclonal Antibody

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Catalog # MBS820795
Unit / Price
  0.03 mL  /  $155 +1 FREE 8GB USB
  0.1 mL  /  $220 +1 FREE 8GB USB
  0.2 mL  /  $295 +1 FREE 8GB USB
Western Blot (WB)
Product Name

NKX2-1, Polyclonal Antibody

Popular Item
Also Known As

Anti-NKX2-1 Antibody

Product Synonym Names
NKX2A; TITF1; TTF1; Homeobox protein Nkx-2.1; Homeobox protein NK-2 homolog A; Thyroid nuclear factor 1; Thyroid transcription factor 1; TTF-1
Antibody/Peptide Pairs
NKX2-1 peptide (MBS822728) is used for blocking the activity of NKX2-1 antibody (MBS820795)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
401
OMIM
gene 610978
3D Structure
ModBase 3D Structure for P43699
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Dog, Pig, Sheep, Zebrafish
Specificity
Recognizes endogenous levels of NKX2-1 protein.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Entrez Gene
7080 (Human); 21869 (Mouse)
SwissProt
P43699 (Human); P50220 (Mouse); P23441 (Rat)
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human NKX2-1. The exact sequence is proprietary.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-NKX2-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-NKX2-1 antibody
Rabbit polyclonal antibody to NKX2-1
Applications Tested/Suitable for anti-NKX2-1 antibody
Western Blot (WB)
Application Notes for anti-NKX2-1 antibody
WB (1/500 - 1/1000)

Western Blot (WB) of anti-NKX2-1 antibody
Western blot analysis of NKX2-1 expression in MAD109 (A), HeLa (B), SP2/0 (C) whole cell lysates.
anti-NKX2-1 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for NKX2-1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
41,737 Da
NCBI Official Full Name
homeobox protein Nkx-2.1 isoform 1
NCBI Official Synonym Full Names
NK2 homeobox 1
NCBI Official Symbol
NKX2-1  [Similar Products]
NCBI Official Synonym Symbols
BCH; BHC; NK-2; TEBP; TTF1; NKX2A; T/EBP; TITF1; TTF-1; NKX2.1
  [Similar Products]
NCBI Protein Information
homeobox protein Nkx-2.1; NK-2 homolog A; thyroid nuclear factor 1; thyroid transcription factor 1; homeobox protein NK-2 homolog A; thyroid-specific enhancer-binding protein
UniProt Protein Name
Homeobox protein Nkx-2.1
UniProt Synonym Protein Names
Homeobox protein NK-2 homolog A; Thyroid nuclear factor 1; Thyroid transcription factor 1; TTF-1; Thyroid-specific enhancer-binding protein; T/EBP
Protein Family
UniProt Gene Name
NKX2-1  [Similar Products]
UniProt Synonym Gene Names
NKX2A; TITF1; TTF1; TTF-1; T/EBP  [Similar Products]
UniProt Entry Name
NKX21_HUMAN
NCBI Summary for NKX2-1
This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TTF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription. [provided by RefSeq, Feb 2014]
UniProt Comments for NKX2-1
NKX2-1: Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Defects in NKX2-1 are the cause of benign hereditary chorea (BHC); also known as hereditary chorea without dementia. BHC is an autosomal dominant movement disorder. The early onset of symptoms (usully before the age of 5) and the observation that in some BHC families the symptoms tend to decrease in adulthood suggests that the disorder results from a developmental disturbance of the brain. BHC is non-progressive and patients have normal or slightly below normal intelligence. There is considerable inter- and intrafamilial variability, including dysarthria, axial distonia and gait disturbances. Defects in NKX2-1 are the cause of choreoathetosis, hypothyroidism, and neonatal respiratory distress (CHNRD). This syndrome include neurological, thyroid, and respiratory problems. Belongs to the NK-2 homeobox family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 14q13

Cellular Component: nucleoplasm; transcription factor complex; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; enzyme binding; DNA binding; sequence-specific DNA binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; axon guidance; positive regulation of transcription, DNA-dependent; response to hormone stimulus; neuron migration; rhythmic process; globus pallidus development; forebrain dorsal/ventral pattern formation; locomotory behavior; negative regulation of transcription from RNA polymerase II promoter; positive regulation of circadian rhythm; Leydig cell differentiation; phospholipid metabolic process; forebrain development; thyroid gland development; oligodendrocyte differentiation; anatomical structure formation; forebrain neuron fate commitment; negative regulation of cell migration; hippocampus development; induction; cerebral cortex GABAergic interneuron differentiation; cerebral cortex cell migration; pituitary gland development; positive regulation of transcription from RNA polymerase II promoter; brain development; negative regulation of transcription, DNA-dependent; negative regulation of transforming growth factor beta receptor signaling pathway; endoderm development; lung development

Disease: Thyroid Carcinoma, Papillary; Chorea, Benign Hereditary; Choreoathetosis And Congenital Hypothyroidism With Or Without Pulmonary Dysfunction
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with anti-NKX2-1 antibody
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