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anti-FLT1 antibody :: Rabbit FLT1 / VEGFR1 Polyclonal Antibody

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Catalog # MBS240174
Unit / Price
  0.05 mg  /  $530 +1 FREE 8GB USB
Immunohistochemistry (IHC)
Product Name

FLT1 / VEGFR1, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal to Human FLT1 / VEGFR1

Product Synonym Names
Anti-FLT1 / VEGFR1 Antibody (N-Terminus) IHC-plus; FLT1; FLT; FLT-1; Fms-related tyrosine kinase 1; SFlt1; VEGF-r1; VEG-R1; Tyrosine-protein kinase FRT; VEGFR-1; Fms-like tyrosine kinase 1; FRT; VEGF receptor 1; VEGFf-rI; VEGFR1; Human FLT1; VEGFR1
Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
165070
3D Structure
ModBase 3D Structure for P17948
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Gibbon, Gorilla, Human
Predicted Reactivity: Monkey, Dog, Horse (at least 90% immunogen sequence identity)
Specificity
Human VEGFR1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, 0.1% sodium azide.
Concentration
0.14 mg/ml (lot specific)
Target Species
Human
Immunogen Description
Synthetic 15 amino acid peptide from N-terminus of human VEGFR1. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%); Monkey, Marmoset, Dog, Panda, Horse, Opossum (93%); Mouse, Rat, Platypus (87%); Bovine, Elephant.
Immunogen Type
Synthetic peptide
Immunogen
FLT1 / VEGFR1 antibody was raised against synthetic 15 amino acid peptide from N-terminus of human VEGFR1. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%); Monkey, Marmoset, Dog, Panda, Horse, Opossum (93%); Mouse, Rat, Platypus (87%); Bovine, Elephant, Rabbit (80%).
Antigen Modification
N-Terminus
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Other Notes
Small volumes of anti-FLT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-FLT1 antibody
FLT1 (fms-like tyrosine kinase/vascular endothelial growth factor receptor 1) is a receptor for VEGR, VEGFB, and PGF. This receptor has a large extracellular domain similar to other members of the fms family and has tyrosine kinase activity. The VEGF kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability.
Applications Tested/Suitable for anti-FLT1 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-FLT1 antibody
IHC-P (5 - 10 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-FLT1 antibody
Anti-VEGFR1 antibody IHC of human placenta, fetal capillary endothelial cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-FLT1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for FLT1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
41,175 Da
NCBI Official Full Name
vascular endothelial growth factor receptor 1 isoform 1
NCBI Official Synonym Full Names
fms-related tyrosine kinase 1
NCBI Official Symbol
NCBI Official Synonym Symbols
FLT; FLT-1; VEGFR1; VEGFR-1
  [Similar Products]
NCBI Protein Information
vascular endothelial growth factor receptor 1; fms-like tyrosine kinase 1; tyrosine-protein kinase FRT; tyrosine-protein kinase receptor FLT; vascular permeability factor receptor; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
UniProt Protein Name
Vascular endothelial growth factor receptor 1
UniProt Synonym Protein Names
Fms-like tyrosine kinase 1; FLT-1; Tyrosine-protein kinase FRT; Tyrosine-protein kinase receptor FLT; FLT; Vascular permeability factor receptor
UniProt Gene Name
UniProt Synonym Gene Names
FLT; FRT; VEGFR1; VEGFR-1; FLT-1; FLT  [Similar Products]
UniProt Entry Name
VGFR1_HUMAN
NCBI Summary for FLT1
This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]
UniProt Comments for FLT1
VEGFR1: a receptor tyrosine kinase of the VEGFR family. Receptor for VEGF, VEGFB and PGF. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. Two splice variant isoforms have been described. Isoform SFlt1 may have an inhibitory role in angiogenesis.

Protein type: EC 2.7.10.1; Kinase, protein; Protein kinase, tyrosine (receptor); Membrane protein, integral; Protein kinase, TK; TK group; VEGFR family

Chromosomal Location of Human Ortholog: 13q12

Cellular Component: extracellular space; focal adhesion; integral to plasma membrane; plasma membrane; receptor complex; endosome

Molecular Function: identical protein binding; vascular endothelial growth factor receptor activity; protein binding; growth factor binding; transmembrane receptor protein tyrosine kinase activity; ATP binding

Biological Process: cell migration; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; positive regulation of phosphoinositide 3-kinase activity; positive regulation of vascular endothelial growth factor receptor signaling pathway; patterning of blood vessels; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of MAP kinase activity; monocyte chemotaxis; positive regulation of angiogenesis; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; blood vessel morphogenesis; sprouting angiogenesis; embryonic morphogenesis; cell differentiation; vascular endothelial growth factor receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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