NP_056200.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
143,741 Da
NCBI Official Full Name
sorbin and SH3 domain-containing protein 1 isoform 2
NCBI Official Synonym Full Names
sorbin and SH3 domain containing 1
NCBI Official Synonym Symbols
CAP; FLAF2; R85FL; SH3D5; SORB1; SH3P12 [Similar Products]
NCBI Protein Information
sorbin and SH3 domain-containing protein 1; SORBS1; ponsin; SH3 domain protein 5; c-Cbl associated protein; Fas-ligand associated factor 2
UniProt Protein Name
Sorbin and SH3 domain-containing protein 1
UniProt Synonym Protein Names
Ponsin; SH3 domain protein 5; SH3P12; c-Cbl-associated protein; CAP
UniProt Synonym Gene Names
UniProt Entry Name
SRBS1_HUMAN
NCBI Summary for SORBS1
This gene encodes a CBL-associated protein which functions in the signaling and stimulation of insulin. Mutations in this gene may be associated with human disorders of insulin resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
UniProt Comments for SORBS1
SORBS1: Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin- stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions. 12 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 10q23.33
Cellular Component: centrosome; nuclear matrix; focal adhesion; zonula adherens; cytosol; cell-substrate adherens junction; lipid raft; nucleoplasm; cell-cell adherens junction; cytoplasm; stress fiber; plasma membrane; nucleus
Molecular Function: protein binding; SH3/SH2 adaptor activity; cytoskeletal protein binding; actin binding; protein kinase binding; insulin receptor binding
Biological Process: focal adhesion formation; positive regulation of glucose import; positive regulation of signal transduction; muscle contraction; cellular response to insulin stimulus; cell-matrix adhesion; positive regulation of glycogen biosynthetic process; stress fiber formation; insulin receptor signaling pathway; positive regulation of lipid biosynthetic process; glucose transport
Research Articles on SORBS1
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Pathways associated with anti-SORBS1 antibody
Diseases associated with anti-SORBS1 antibody
Organs/Tissues associated with anti-SORBS1 antibody
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