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anti-PGES antibody :: Rabbit PGES / PTGES Polyclonal Antibody

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Catalog # MBS240155
Unit / Price
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  0.05 mg  /  $530 +1 FREE 8GB USB
Product Name

PGES / PTGES, Polyclonal Antibody

Popular Item
Full Product Name

Rabbit Polyclonal to Human PGES / PTGES

Product Synonym Names
Anti-PGES / PTGES Antibody (Cytoplasmic Domain) IHC-plus; PTGES; MGST1-L1; MGST1-like 1; MPGES; MPGES-1; PGES; PIG12; PP102; TP53I12; MGST1L1; MPGES1; PP1294; MGST-IV; p53-induced gene 12 protein; Prostaglandin E synthase; Human PGES; PTGES
Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
605172
3D Structure
ModBase 3D Structure for O14684
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Gibbon, Gorilla, Human, Rabbit
Predicted Reactivity: Monkey, Dog (at least 90% immunogen sequence identity)
Specificity
Human PTGES. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, 0.1% sodium azide.
Concentration
1 mg/ml (lot specific)
Target Species
Human
Immunogen Description
Synthetic 13 amino acid peptide from 1st cytoplasmic domain of human PTGES.
Immunogen Type
Synthetic peptide
Immunogen
PGES / PTGES antibody was raised against synthetic 13 amino acid peptide from 1st cytoplasmic domain of human PTGES. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Rabbit (100%); Marmoset, Dog, Elephant, Panda, Pike (92%); Bovine, Hamster, Pig, Xenopus (85%).
Antigen Modification
Cytoplasmic Domain
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Other Notes
Small volumes of anti-PGES antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PGES antibody
Prostaglandin E Synthase (PGES) is a membrane associated protein involved in eicosanoid and glutathione metabolism as part of the arachidonic acid signaling pathway. The expression of PGES is induced by the proinflammatory cytokine IL-1B and its activity is glutathione dependent. PGES is also expressed at high levels in P53 expressing cells.
Applications Tested/Suitable for anti-PGES antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-PGES antibody
IHC-P (5 - 10 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-PGES antibody
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
anti-PGES antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-PGES antibody
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
anti-PGES antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-PGES antibody
Anti-PGES / PTGES antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-PGES antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-PGES antibody
Anti-PGES / PTGES antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-PGES antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-PGES antibody
Anti-PGES / PTGES antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-PGES antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for PGES. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
17,102 Da
NCBI Official Full Name
prostaglandin E synthase
NCBI Official Synonym Full Names
prostaglandin E synthase
NCBI Official Symbol
PTGES  [Similar Products]
NCBI Official Synonym Symbols
PGES; MPGES; PIG12; PP102; PP1294; MGST-IV; MGST1L1; TP53I12; mPGES-1; MGST1-L1
  [Similar Products]
NCBI Protein Information
prostaglandin E synthase; MGST1-like 1; p53-induced gene 12 protein; p53-induced apoptosis protein 12; glutathione S-transferase 1-like 1; microsomal prostaglandin E synthase 1; microsomal prostaglandin E synthase-1; tumor protein p53 inducible protein 12; microsomal glutathione S-transferase 1-like 1
UniProt Protein Name
Prostaglandin E synthase
UniProt Synonym Protein Names
Microsomal glutathione S-transferase 1-like 1; MGST1-L1; Microsomal prostaglandin E synthase 1; MPGES-1; p53-induced gene 12 protein
UniProt Gene Name
PTGES  [Similar Products]
UniProt Synonym Gene Names
MGST1L1; MPGES1; PGES; PIG12; MGST1-L1; MPGES-1  [Similar Products]
UniProt Entry Name
PTGES_HUMAN
NCBI Summary for PGES
The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008]
UniProt Comments for PGES
PTGES: Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Belongs to the MAPEG family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Lipid Metabolism - arachidonic acid; Isomerase; EC 5.3.99.3; Nuclear envelope

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: endoplasmic reticulum membrane; membrane; perinuclear region of cytoplasm; nuclear envelope lumen; integral to membrane

Molecular Function: glutathione binding; prostaglandin-E synthase activity

Biological Process: negative regulation of cell proliferation; chronic inflammatory response; response to retinoic acid; response to cytokine stimulus; cyclooxygenase pathway; arachidonic acid metabolic process; response to lipopolysaccharide; prostaglandin biosynthetic process; response to calcium ion; signal transduction; response to organic cyclic substance; acute inflammatory response; prostaglandin metabolic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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