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anti-ABCA12 antibody :: Goat ABCA12 Polyclonal Antibody

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Catalog # MBS422139
Unit / Price
  0.1 mg  /  $225 +1 FREE 8GB USB
anti-ABCA12 antibody
Product Name

ABCA12, Polyclonal Antibody

Also Known As

Goat anti-ABCA12 Antibody

Product Synonym Names
ABCA12; ATP-binding cassette, sub-family A (ABC1), member 12; DKFZp434G232; FLJ41584; ICR2B; LI2; ATP-binding cassette, sub-family A, member 12; ABCA12 antibody; ATP-binding cassette; sub-family A (ABC1); member 12 antibody; DKFZp434G232 antibody; FLJ41584 antibody; ICR2B antibody; LI2 antibody; ATP-binding cassette; sub-family A; member 12 antibody
Antibody/Peptide Pairs
ABCA12 peptide (MBS426242) is used for blocking the activity of ABCA12 antibody (MBS422139)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
Immunogen Sequence
Species Reactivity
Expected from sequence similarity: Human, Dog
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
100ug specific antibody in 200ul (lot specific)
Peptide with sequence C-KDQKSYETADTSSQ, from the internal regon (near C terminus) of the protein sequence according to NP_775099.2; NP_056472.2.
Internal region (near C Terminus)
This antibody is expected to recognize both reported isoforms (NP_775099.2; NP_056472.2).
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-ABCA12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ABCA12 antibody
Peptide ELISA (EIA)
Application Notes for anti-ABCA12 antibody
Peptide ELISA: Antibody detection limit dilution 1: 1000.
Western Blot: Preliminary experiments gave an approx 35kDa band in Human Placenta, Skin and Testis lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 193kDa according to NP_775099.2 and of 257kDa according to NP_056472.2. The 35kDa band was successfully blocked by incubation with the immunizing peptide.
NCBI/Uniprot data below describe general gene information for ABCA12. It may not necessarily be applicable to this product.
NCBI Accession #
NCBI Related Accession #
Manufactured in an ISO 9001:2015 Certified Laboratory.NP_056472.2[Other Products]
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
256,960 Da
NCBI Official Full Name
ATP-binding cassette sub-family A member 12 isoform a
NCBI Official Synonym Full Names
ATP binding cassette subfamily A member 12
NCBI Official Symbol
ABCA12  [Similar Products]
NCBI Official Synonym Symbols
  [Similar Products]
NCBI Protein Information
ATP-binding cassette sub-family A member 12
UniProt Protein Name
ATP-binding cassette sub-family A member 12
UniProt Synonym Protein Names
ATP-binding cassette transporter 12; ATP-binding cassette 12
Protein Family
UniProt Gene Name
ABCA12  [Similar Products]
UniProt Synonym Gene Names
ABC12; ATP-binding cassette 12  [Similar Products]
UniProt Entry Name
NCBI Summary for ABCA12
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily, which is the only major ABC subfamily found exclusively in multicellular eukaryotes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCA12
ABCA12: Probable transporter involved in lipid homeostasis. ABCA12 mutations are a cause of different subtypes of autosomal recessive congenital ichthyosis (ARCI), including Harlequin ichthyosis (HI), lamellar ichthyosis (LI) and non- bullous congenital ichthyosiform erythroderma (NCIE). HI shows the most severe phenotype. NCIE and LI are clinically characterized by fine, whitish scales on a background of erythematous skin, and large, thick, dark scales over the entire body without serious background erythroderma, respectively. Defects in ABCA12 are the cause of ichthyosis harlequin (HI). A very severe skin disorder in which the neonate is born with a thick covering of armor-like scales. The skin dries out to form hard diamond-shaped plaques separated by fissures, resembling 'armor plating'. The normal facial features are severely affected, with distortion of the lips (eclabion), eyelids (ectropion), ears, and nostrils. Affected babies are often born prematurely and rarely survive the perinatal period. Defects in ABCA12 are the cause of ichthyosis lamellar type 2 (LI2). A non-bullous ichthyosis, a skin disorder characterized by abnormal cornification of the epidermis. It is one the most severe forms of ichthyoses apparent at birth and persisting throughout life. LI patients are born encased in a tight, shiny, translucent covering called collodion membrane. Over the first weeks of life, the collodion membrane is gradually replaced by generalized large, dark brown, plate-like scales with minimal to no erythroderma. Tautness of facial skin commonly results in ectropion, eclabium and scarring alopecia of the scalp. Common complications are severe heat intolerance and recurrent ear infections. Defects in ABCA12 are a cause of erythroderma, ichthyosiform, congenital non-bullous (NCIE). A non- bullous ichthyosis, a skin disorder characterized by abnormal cornification of the epidermis. Most affected individuals are born with a tight, shiny, translucent covering called collodion membrane. The collodion membrane subsequently evolves into generalized scaling and intense redness of the skin. Clinical features are milder than in lamellar ichthyoses and demonstrate a greater variability in the intensity of erythema, size and type of scales. In contrast to lamellar ichthyoses, scales are usually white, fine and powdery, and palms and soles are severely affected. Patients suffer from palmoplantar keratoderma, often with painful fissures, digital contractures, and loss of pulp volume. Belongs to the ABC transporter superfamily. ABCA family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; Transporter, ABC family; Membrane protein, integral; Membrane protein, multi-pass; Transporter

Chromosomal Location of Human Ortholog: 2q34

Cellular Component: cytoplasm; cytosol; integral to membrane; mitochondrial inner membrane; plasma membrane

Molecular Function: apolipoprotein A-I receptor binding; ATP binding; ATPase activity, coupled to transmembrane movement of substances; lipid transporter activity; lipid-transporting ATPase activity; protein binding; receptor binding

Biological Process: alveolus development; cellular homeostasis; keratinization; lipid homeostasis; lipid transport; metabolic process; phospholipid efflux; regulated secretory pathway; secretion by cell; surfactant homeostasis; transmembrane transport

Disease: Ichthyosis, Congenital, Autosomal Recessive 4a; Ichthyosis, Congenital, Autosomal Recessive 4b
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