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anti-AADACL1 antibody :: Goat AADACL1 Polyclonal Antibody

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Catalog # MBS421592
Unit / Price
  0.1 mg  /  $225 +1 FREE 8GB USB
anti-AADACL1 antibody
Product Name

AADACL1, Polyclonal Antibody

Also Known As

Goat anti-AADACL1 Antibody

Product Synonym Names
AADACL1; arylacetamide deacetylase-like 1; AADACL1 antibody; arylacetamide deacetylase-like 1 antibody
Antibody/Peptide Pairs
AADACL1 peptide (MBS425438) is used for blocking the activity of AADACL1 antibody (MBS421592)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
440
Immunogen Sequence
RTRNSYIKWL DQN
OMIM
613234
Clonality
Polyclonal
Host
Goat
Species Reactivity
Expected from sequence similarity: Human, Mouse, Dog
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence C-RTRNSYIKWLDQN, from the C Terminus of the protein sequence according to NP_065843.3.
Epitope
C Terminus
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-AADACL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-AADACL1 antibody
Peptide ELISA (EIA)
Application Notes for anti-AADACL1 antibody
Peptide ELISA: Antibody detection limit dilution 1: 1000.
Western Blot: Preliminary experiments gave an approx 26-28kDa band in Human Brain (Amygdala, Cerebellum, Hippocampus) lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 49.1kDa according to NP_065843.3. The 26-28kDa band was successfully blocked by incubation with the immunizing peptide.
NCBI/Uniprot data below describe general gene information for AADACL1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
31,168 Da
NCBI Official Full Name
neutral cholesterol ester hydrolase 1 isoform b
NCBI Official Synonym Full Names
neutral cholesterol ester hydrolase 1
NCBI Official Symbol
NCEH1  [Similar Products]
NCBI Official Synonym Symbols
NCEH; AADACL1
  [Similar Products]
NCBI Protein Information
neutral cholesterol ester hydrolase 1
UniProt Protein Name
Neutral cholesterol ester hydrolase 1
UniProt Synonym Protein Names
Arylacetamide deacetylase-like 1
UniProt Gene Name
NCEH1  [Similar Products]
UniProt Synonym Gene Names
AADACL1; KIAA1363; NCEH  [Similar Products]
UniProt Entry Name
NCEH1_HUMAN
UniProt Comments for AADACL1
AADACL1: a single-pass type II membrane microsomal protein. Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (acetyl-glyceryl-ether-phosphorylcholine). Elevated in invasive cancer cells from several different tumor types. May be involved in the elevated neutral ether lipid content and elevated LPA signaling in cancer cells. May be responsible for cholesterol ester hydrolysis in macrophages, thereby contributing to the development of atherosclerosis. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds. May contribute to cancer pathogenesis by promoting tumor cell migration. A key enzymatic node regulating an ether lipid signaling network in cancer; regulates MAGE and lysophospholipid levels in invasive cancer cells. Three alternatively spliced human isoforms have been described.

Protein type: Membrane protein, integral; EC 3.1.1.-; Hydrolase

Chromosomal Location of Human Ortholog: 3q26.31

Cellular Component: endoplasmic reticulum membrane; integral to membrane; membrane

Molecular Function: sterol esterase activity

Biological Process: lipid catabolic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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