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anti-F11R antibody :: Goat F11R/JAM-A Polyclonal Antibody

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Catalog # MBS421976
Unit / Price
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  0.1 mg  /  $300 +1 FREE 8GB USB
Western Blot (WB)
Product Name

F11R/JAM-A, Polyclonal Antibody

Popular Item
Full Product Name

Goat anti-F11R/JAM-A Antibody

Product Synonym Names
F11R; F11 receptor; CD321; JAM; JAM-1; JAM-A; JAM1; JAMA; JCAM; KAT; PAM-1; OTTHUMP00000027880; OTTHUMP00000027881; junctional adhesion molecule 1; junctional adhesion molecule A; platelet F11 receptor; platelet adhesion molecule; F11R antibody; F11 receptor antibody; CD321 antibody; JAM antibody; JAM-1 antibody; JAM-A antibody; JAM1 antibody; JAMA antibody; JCAM antibody; KAT antibody; PAM-1 antibody; OTTHUMP00000027880 antibody; OTTHUMP00000027881 antibody; junctional adhesion molecule 1 antibody; junctional adhesion molecule A antibody; platelet F11 receptor antibody; platelet adhesion molecule antibody; F11R / JAM-A
Product Synonym Gene Name
Antibody/Peptide Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
QPSARSEGEF KQTS
OMIM
605721
Clonality
Polyclonal
Host
Goat
Species Reactivity
Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Pig
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence C-QPSARSEGEFKQTS, from the C Terminus of the protein sequence according to NP_058642.1.
Epitope
C Terminus
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-F11R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-F11R antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-F11R antibody
Peptide ELISA: Antibody detection limit dilution 1: 2000.
Western Blot: Approx 38kDa band observed in Human Peripheral Blood Mononucleocyte lysates (calculated MW of 32.6kDa according to NP_058642.1). The observed molecular weight corresponds to earlier findings with different antibodies from other commercial sources. Recommended concentration: 0.3-2ug/ml.

Western Blot (WB) of anti-F11R antibody
(0.3ug/ml) staining of Human Peripheral Blood Mononucleocyte lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-F11R antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for F11R. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
27,208 Da
NCBI Official Full Name
junctional adhesion molecule A
NCBI Official Synonym Full Names
F11 receptor
NCBI Official Symbol
NCBI Official Synonym Symbols
JAM; KAT; JAM1; JAMA; JCAM; CD321; PAM-1
  [Similar Products]
NCBI Protein Information
junctional adhesion molecule A
UniProt Protein Name
Junctional adhesion molecule A
UniProt Synonym Protein Names
Junctional adhesion molecule 1; JAM-1; Platelet F11 receptor; Platelet adhesion molecule 1; PAM-1; CD_antigen: CD321
UniProt Gene Name
UniProt Synonym Gene Names
JAM1; JCAM; JAM-A; JAM-1; PAM-1  [Similar Products]
UniProt Entry Name
JAM1_HUMAN
NCBI Summary for F11R
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008]
UniProt Comments for F11R
JAM-A: Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus. Belongs to the immunoglobulin superfamily.

Protein type: Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 1q21.2-q21.3

Cellular Component: cell junction; cytoplasmic vesicle; integral to membrane; intercellular junction; microtubule cytoskeleton; plasma membrane; tight junction

Molecular Function: PDZ domain binding; protein binding; viral receptor activity

Biological Process: actomyosin structure organization and biogenesis; cell adhesion; entry of virus into host cell; extracellular matrix organization and biogenesis; inflammatory response; intestinal absorption; leukocyte migration; positive regulation of blood pressure; positive regulation of GTPase activity; regulation of cytokine production; response to radiation; transforming growth factor beta receptor signaling pathway
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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