NP_001295022.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
44,665 Da
NCBI Official Full Name
transcription factor GATA-4 isoform 1
NCBI Official Synonym Full Names
GATA binding protein 4
NCBI Protein Information
transcription factor GATA-4
UniProt Protein Name
Transcription factor GATA-4
UniProt Synonym Protein Names
GATA-binding factor 4
UniProt Entry Name
GATA4_HUMAN
NCBI Summary for GATA4
This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function, and is necessary for normal testicular development. Mutations in this gene have been associated with cardiac septal defects. Additionally, alterations in gene expression have been associated with several cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
UniProt Comments for GATA4
GATA4: a conserved and ubiquitous member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. May regulate a set of cardiac-specific genes and play a crucial role in cardiogenesis. Defects are a cause of atrial septal defect 2 (ASD2). ASD2 is an autosomal dominant condition with atrial septal defect and other congenital heart disease but no conduction defects or noncardiac abnormalities.
Protein type: Transcription factor; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 8p23.1-p22
Cellular Component: nucleoplasm; nuclear chromatin; nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; NFAT protein binding; transcription activator binding; DNA binding; zinc ion binding; sequence-specific DNA binding; transcription coactivator activity; chromatin binding; transcription factor binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; cardiac muscle hypertrophy; negative regulation of autophagy; positive regulation of transcription, DNA-dependent; embryonic heart tube anterior/posterior pattern formation; Sertoli cell differentiation; Wnt receptor signaling pathway through beta-catenin; BMP signaling pathway; cell-cell signaling; regulation of transcription, DNA-dependent; embryonic digestive tract morphogenesis; embryonic foregut morphogenesis; heart looping; positive regulation of BMP signaling pathway; positive regulation of cardiac muscle cell proliferation; response to drug; response to retinoic acid; in utero embryonic development; male gonad development; gastrulation with mouth forming second; positive regulation of angiogenesis; response to mechanical stimulus; endoderm formation; response to estrogen stimulus; positive regulation of cardioblast differentiation; positive regulation of transcription from RNA polymerase II promoter; spermatogenesis; blood coagulation; endoderm development
Disease: Ventricular Septal Defect 1; Tetralogy Of Fallot; Atrial Septal Defect 2; Testicular Anomalies With Or Without Congenital Heart Disease; Atrioventricular Septal Defect 4
Research Articles on GATA4
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Products associated with anti-GATA4 antibody
Pathways associated with anti-GATA4 antibody
Diseases associated with anti-GATA4 antibody
Organs/Tissues associated with anti-GATA4 antibody
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